Fecal Calprotectin May Predict Adverse Pregnancy-Related Outcomes in Patients with Inflammatory Bowel Disease.

Digestive Diseases and Sciences
Parul TandonVivian M Huang

Abstract

The role of fecal calprotectin in predicting pregnancy-related outcomes in inflammatory bowel disease (IBD) remains unknown. To determine whether increased fecal calprotectin during pregnancy is associated with adverse pregnancy outcomes in IBD. This is a multicenter cohort study of women with IBD who underwent fecal calprotectin monitoring during pregnancy. Fecal calprotectin levels were stratified by trimester, and adverse pregnancy-related outcomes were recorded. The Mann-Whitney U test assessed differences between continuous variables, whereas categorical variables were compared using the Chi-squared test. Eighty-five women with IBD were included. First trimester fecal calprotectin was higher in patients who underwent emergency Cesarean birth compared to those who had a vaginal delivery (503 ug/g, IQR 1554.3 ug/g vs. 130 ug/g, IQR 482 ug/g, p = .030, respectively) and in those who delivered infants with low birth weight compared to normal birth weight (1511 ug/g, IQR 579 ug/g vs. 168 ug/g, IQR 413 ug/g, p = .049, respectively). Third trimester fecal calprotectin was higher in those with non-elective induction of labor (334.5 ug/g, IQR 1411.0 ug/g) compared to those with spontaneous delivery (116.5 ug/g, IQR 227.1 ug/g) (p =...Continue Reading

References

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Jul 16, 2019·Journal of Clinical Gastroenterology·Parul TandonVivian W Huang

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Citations

Aug 28, 2020·Alimentary Pharmacology & Therapeutics·Kristel K Leung, Vivian Huang
Mar 23, 2021·Gastroenterología y hepatología·Paulina Nuñez FUdo Kronberg

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