Fecal Clostridiales distribution and short-chain fatty acids reflect bowel habits in irritable bowel syndrome

Environmental Microbiology
Giorgio GargariSimone Guglielmetti

Abstract

Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is classified according to bowel habits as IBS with constipation (IBS-C), with diarrhea (IBS-D), with alternating constipation and diarrhea (IBS-M), and unsubtyped (IBS-U). The mechanisms leading to the different IBS forms are mostly unknown. This study aims to evaluate whether specific fecal bacterial taxa and/or short-chain fatty acids (SCFAs) can be used to distinguish IBS subtypes and are relevant for explaining the clinical differences between IBS subcategories. We characterized five fecal samples collected at 4-weeks intervals from 40 IBS patients by 16S rRNA gene profiling and SCFA quantification. Finally, we investigated the potential correlations in IBS subtypes between the fecal microbial signatures and host physiological and clinical parameters. We found significant differences in the distribution of Clostridiales OTUs among IBS subtypes and reduced levels of SCFAs in IBS-C compared to IBS-U and IBS-D patients. Correlation analyses showed that the diverse representation of Clostridiales OTUs between IBS subtypes was associated with altered levels of SCFAs; furthermore, the same OTUs and SCFAs were associated with the fecal cytokine levels ...Continue Reading

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Sep 26, 2019·Journal of Neural Transmission·Manon DefayeFrédéric Antonio Carvalho
Nov 22, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Giovanni BarbaraFernando Azpiroz
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Jan 28, 2021·BMC Gastroenterology·Ilnar F ShaidullovGuzel F Sitdikova
Feb 25, 2021·Applied Microbiology and Biotechnology·Junpeng WangTianzhong Yan
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May 28, 2021·Scientific Reports·Giorgio GargariSimone Guglielmetti
Jun 29, 2021·Médecine sciences : M/S·Frédérique LajoieLucie Etienne-Mesmin
Aug 3, 2021·Frontiers in Microbiology·Qian QinSuying Ding

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