Fecal Galectin-3: A New Promising Biomarker for Severity and Progression of Colorectal Carcinoma

Mediators of Inflammation
Milan JovanovicIvan Jovanovic

Abstract

The aim of the study was to determine systemic and fecal values of galectin-3 and pro- and anti-inflammatory cytokines in patients with CRC and the relationship with clinicopathological aspects. Concentrations of galectin-3, TNF-α, TGF-β, IL-10, and IL-1β were analyzed in samples of blood and stool of 60 patients with CRC. Systemic concentration of TNF-α was significantly lower in patients with severe diseases (advanced TNM stage, nuclear grade, and poor histological differentiation) as in patients with more progressive CRC (lymph and blood vessel invasion, presence of metastasis). Fecal values of anti-inflammatory cytokines TGF-β and IL-10 were increased in patients with severe stadium of CRC. Fecal concentration of Gal-3 was enhanced in CRC patients with higher nuclear grade, poor tumor tissue differentiation, advanced TNM stage, and metastatic disease. Gal-3/TNF-α ratio in sera and feces had a higher trend in patients with severe and advanced diseases. Positive correlation between fecal Gal-3 and disease severity, tumor progression, and biomarkers AFP and CEA, respectively, was also observed. Predomination of Gal-3 in patients with advanced diseases may implicate on its role in limiting ongoing proinflammatory processes. The...Continue Reading

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Citations

May 28, 2020·Biomolecules·Ivan SrejovicGvozden Rosic
Nov 8, 2018·Gastroenterology Research and Practice·Mladen PavlovicIvan Jovanovic
Dec 5, 2019·World Journal of Gastroenterology : WJG·Marina JovanovicNatasa Zdravkovic
Sep 3, 2019·Pathology, Research and Practice·Chengyan WangLijuan Pang
Jan 26, 2021·Cellular Immunology·Preeti Moar, Ravi Tandon
Feb 23, 2021·International Reviews of Immunology·Carolina Frizzera DiasRita Mattiello

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

Gal
SPSS

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