Abstract
Disease activity and severity of ulcerative colitis (UC) is assessed using colonoscopy, which is invasive, costly and has poor patient acceptability. The role of non-invasive biomarkers of intestinal inflammation in the evaluation of patients with UC is not known. The aim of the study was to examine the role of serum C-reactive protein (SCRP), fecal myeloperoxidase (FMPO) and fecal lactoferrin (FLF) in assessing disease severity, activity and response to therapy. Consecutive patients with idiopathic UC (IUC) attending our hospital from July 2005 to September 2006 were studied. All underwent clinical, endoscopic and histological assessment for disease activity, extent, severity and estimation of SCRP, FMPO and FLF levels at baseline and follow up (FU). An equal number of healthy age-matched controls were studied for biomarker levels. A total of 37 patients (mean age 37 +/- 12 years) were studied. All three biomarkers were elevated more often in the cases than in the controls (all P = 0.000). Cases with severe IUC had higher CRP, MPO and FLF titers than those without severe IUC. At FU, a significant fall in biomarker levels paralleled the reduction in Mayo's scores. All three biomarkers showed a high degree of correlation with ea...Continue Reading
References
Jan 1, 1979·Gut·N A BuckellJ Wadsworth
May 1, 1992·Journal of Clinical Microbiology·R L GuerrantA G Lee
Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Feb 1, 1988·Journal of Clinical Gastroenterology·C PranteraS Mariotti
Jan 1, 1986·Gut·P GomesG Holdstock
May 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·B ShineJ Landon
Mar 1, 1982·The Journal of Investigative Dermatology·P P BradleyG Rothstein
Jan 1, 1983·Digestion·L DescosJ Fermanian
Aug 1, 1982·European Journal of Clinical Investigation·E A FaganM B Pepys
Nov 1, 1994·Gastroenterology·A K Rustgi
Apr 1, 1995·Scandinavian Journal of Gastroenterology·A MoranP Asquith
Mar 1, 1994·Baillière's Clinical Gastroenterology·C B Williams, S Nicholls
Jul 11, 1998·The Kurume Medical Journal·T Saiki
Sep 28, 1999·Scandinavian Journal of Gastroenterology. Supplement·A van der Sluys VeerC B Lamers
Jul 13, 2000·Gastroenterology·J A TibbleI Bjarnason
Aug 15, 2000·Gut·K GeboesR Löfberg
Apr 24, 2001·The American Journal of Gastroenterology·P SangfeltY Raab
Feb 28, 2002·The American Journal of Gastroenterology·Masanobu KayazawaKen-ichi Katsu
Apr 11, 2002·European Journal of Gastroenterology & Hepatology·Andrew P PoullisMichael A Mendall
Jul 24, 2002·The American Journal of Gastroenterology·Christer G B PetersonMarie Carlson
Jun 19, 2003·The Journal of Clinical Investigation·Mark B Pepys, Gideon M Hirschfield
Jun 24, 2003·The American Journal of Gastroenterology·Sunanda V KaneStephen B Hanauer
Jul 6, 2004·The American Journal of Gastroenterology·Asher KornbluthUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Jul 27, 2005·Inflammatory Bowel Diseases·Craig A SolemWilliam J Sandborn
Nov 25, 2005·Inflammatory Bowel Diseases·Jost LanghorstGustav J Dobos
Feb 14, 2006·Gut·S VermeireP Rutgeerts
Jul 14, 2006·Digestion·Liaz ZilbermanIris Dotan
Jul 14, 2006·International Journal of Colorectal Disease·Renata D'IncàGiacomo Carlo Sturniolo
Citations
Mar 16, 2011·Journal of Gastroenterology and Hepatology·Ali DaneshmandAhmad Reza Dehpour
Jul 23, 2011·Journal of Gastroenterology and Hepatology·Thomas A JuddSteven T Leach
Nov 11, 2011·World Journal of Gastroenterology : WJG·Chien-Chang ChenMan-Shan Kong
Feb 5, 2014·Biochemistry. Biokhimii︠a︡·O M PanasenkoA V Sokolov
Apr 18, 2014·Indian Journal of Pathology & Microbiology·Chetana VaishnaviSudesh Prabhakar
Feb 22, 2012·Digestive Diseases and Sciences·Ibrahim MasoodiKartar Singh
Apr 17, 2012·Gastroenterology Clinics of North America·Bincy P Abraham, Sunanda Kane
May 3, 2011·Gastroenterology·James D Lewis
May 13, 2015·The American Journal of Gastroenterology·Mahmoud H MosliBrian G Feagan
May 27, 2016·Journal of Crohn's & Colitis·Fernando MagroUNKNOWN Portuguese IBD group [GEDII]
Jan 8, 2017·Journal of Animal Physiology and Animal Nutrition·D N LeeC F Weng
Jan 14, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xiao WangJianhua Wang
Jan 2, 2015·Therapeutic Advances in Gastroenterology·Frank S LehmannChristoph Beglinger
Dec 23, 2017·Inflammatory Bowel Diseases·Mirko Di RuscioGiovanni Latella
Nov 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Kelley Mk HaarbergMichael J Wannemuehler
Dec 12, 2012·Nature Reviews. Gastroenterology & Hepatology·Richard L GuerrantAldo A M Lima
Jan 22, 2019·Journal of Digestive Diseases·Lei Min YuBin Lu
Dec 18, 2013·Scandinavian Journal of Gastroenterology·Darina KohoutovaJan Bures
Jun 7, 2019·Journal of Pediatric Gastroenterology and Nutrition·Betty LanyeroVibeke B Christensen
Apr 18, 2019·Journal of Clinical Gastroenterology·Cong DaiQin Cao
Jun 7, 2020·Journal of Crohn's & Colitis·Fernando MagroRoger Feakins
Apr 12, 2018·Revista da Associação Médica Brasileira·Ana Paula Signori UrbanoAna Lucia Anjos Ferreira
May 20, 2017·Mediators of Inflammation·Gilles DuvoisinSteven T Leach
Jul 1, 2020·Advanced Healthcare Materials·Sufeng ZhangGiovanni Traverso
Jul 9, 2020·Biomedicines·Eran ZittanMarc S Berns
Oct 1, 2016·World Journal of Gastroenterology : WJG·Gautam Ray
Jan 25, 2018·Mucosal Immunology·J B WechslerP J Bryce
Apr 23, 2021·PloS One·Muhammad Ikhtear UddinFirdausi Qadri
Jul 14, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Cailan LiQiang Lu