PMID: 9187619Jun 1, 1997Paper

Fecal losses of sterols and bile acids induced by feeding rats guar gum are due to greater pool size and liver bile acid secretion

The Journal of Nutrition
C MoundrasC Demigné

Abstract

The effect of dietary guar gum (GG, 7.5%) on lipid metabolism and on bile acid secretion and reabsorption was investigated in rats adapted to cholesterol-free or 0.3% cholesterol diets. Compared with controls (fiber-free/cholesterol-free), rats fed cholesterol had significantly elevated plasma and liver cholesterol and triglyceride. In these rats, GG had a potent plasma cholesterol-lowering effect and also counteracted the liver accumulation of triglyceride and cholesterol esters. Fecal excretion of sterols, the major route of cholesterol elimination, was markedly enhanced by GG, especially in rats fed the cholesterol-containing diet (P < 0.001). The biliary bile acid flux into the small intestine was enhanced by dietary cholesterol (+30%) or GG (+52%) or both (P < 0.001). The fecal excretion of bile acids was significantly elevated by GG alone (+74%) and by dietary cholesterol (+190%). Small intestine reabsorption of bile acids appears to be significantly enhanced by GG, which also enhanced the transfer of bile acids into the large intestine, hence a greater fecal loss of steroids, although bile acid reabsorption was very effective in the cecum. GG feeding induced liver hydroxymethyl-glutaryl coenzyme A (HMG CoA) reductase, ev...Continue Reading

References

Feb 1, 1992·The Journal of Nutrition·C L RedardB O Schneeman
Oct 1, 1991·Biochimica Et Biophysica Acta·I BjörkhemU Andersson
Jul 1, 1989·The Journal of Clinical Investigation·E F StangeH Ditschuneit
Jun 1, 1988·The American Journal of Clinical Nutrition·I T JohnsonJ C Brown
Dec 1, 1988·The Journal of Nutrition·D M NeyF L Shinnick
Aug 1, 1988·The American Journal of Clinical Nutrition·J H Meyer, J E Doty
Jul 1, 1974·The Biochemical Journal·C Remesy, C Demigne
Aug 1, 1983·The Journal of Nutrition·K S Poksay, B O Schneeman
Sep 1, 1983·The British Journal of Nutrition·J M GeeI T Johnson
Jul 1, 1984·The Journal of Nutrition·B O SchneemanM Lefevre
Aug 1, 1995·The British Journal of Nutrition·I C Gelissen, M A Eastwood
Sep 14, 1995·Biochimica Et Biophysica Acta·M L FavierC Rémésy
Sep 1, 1994·The British Journal of Nutrition·P D OvertonL M Morgan
Jan 1, 1993·Gastroenterology·J LillienauA F Hofmann
Jan 1, 1993·Nutrition Research Reviews·S SethiC M Williams

❮ Previous
Next ❯

Citations

Jul 22, 2011·Food & Function·Purnima Gunness, Michael John Gidley
Mar 23, 2012·Environmental Health and Preventive Medicine·Rupal A Vasant, A V R L Narasimhacharya
Feb 2, 2012·Journal of Nutritional Science and Vitaminology·Naomichi NishimuraMichihiro Fukushima
Jan 31, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Chikkanna K Raghavendra, Krihnapura Srinivasan
Nov 10, 1998·The Journal of Nutrition·S GorinsteinS Trakhtenberg
Apr 14, 2006·The British Journal of Nutrition·Takashi FushimiToshinao Goda
Oct 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·Santosh Kumar MauryaArvind Kumar Srivastava
Nov 23, 2013·Critical Reviews in Food Science and Nutrition·Imran HayatShaukat Bashir
Dec 9, 2016·Journal of Nutritional Science and Vitaminology·Kae InagakiHisako Hotta
Apr 6, 2006·European Journal of Nutrition·Laëtitia RobertChristian Rémésy
Mar 27, 2007·The British Journal of Nutrition·Liyanage RuviniMichihiro Fukushima
Sep 24, 2011·Oxidative Medicine and Cellular Longevity·Nishant P Visavadiya, A V R L Narasimhacharya
Jun 10, 2017·Tropical Animal Health and Production·Mohamad Hamed SalajeghehAkbar Yaghobfar
Apr 4, 2017·Molecular Nutrition & Food Research·Kyu-Ho HanMichihiro Fukushima
Nov 17, 2017·Journal of Animal Physiology and Animal Nutrition·M H SalajeghehM Salarmoini
Oct 21, 2006·Molecular Nutrition & Food Research·Nishant P Visavadiya, Amaravadi V R L Narasimhacharya
Dec 29, 2000·Bioscience, Biotechnology, and Biochemistry·Y YamamotoS Iibata
Dec 20, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Guorong XuGerald Salen
Aug 29, 2014·Journal of Dietary Supplements·Sanjay S Karn, A V R L Narasimhacharya
Apr 15, 2010·Pakistan Journal of Biological Sciences : PJBS·A M Ezz El-Arab
Aug 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P A HepburnM Smith
Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Catherine NicolleChristian Rémésy
May 23, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Nishant P Visavadiya, A V R L Narasimhacharya
Sep 4, 2003·Journal of Agricultural and Food Chemistry·Ryszard KrzeminskiSimon Trakhtenberg
Mar 21, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nishant P Visavadiya, A V R L Narasimhacharya
Feb 16, 2007·Journal of Agricultural and Food Chemistry·Il Jin ChoTae Youl Ha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.