Fecal microbiota in horses with asthma

Journal of Veterinary Internal Medicine
Mathilde Leclere, Marcio C Costa

Abstract

Gastrointestinal microbiota can be influenced by several factors, including diet and systemic inflammation, and in turn could act as a modulator of the allergic response. Fecal microbiota of horses with asthma has not been described. Analyze the bacterial fecal microbiota of horses with and without asthma under different environment and diet conditions, during both remission and exacerbation. Prospective observational study. Feces from 6 asthmatic and 6 healthy horses were collected under 3 different conditions: on pasture, housed indoors receiving good quality hay ("good hay"), and housed indoors receiving poor quality hay ("dusty hay"). Sequencing was performed using an Illumina MiSeq platform and data were processed using the software mothur v.1.41.3 and LEfSe. In horses with asthma, low-abundance bacteria were more affected by changes in environment and diet (ie, when horses were experiencing an exacerbation), as shown by changes in membership and results from the LEfSe analysis. There was a significant increase in the relative abundance of Fibrobacter in healthy horses eating hay, a change that was not observed in horses with asthma. The intestinal microbiota of horses with asthma does not adapt in the same way to changes ...Continue Reading

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Datasets Mentioned

BETA
PRJNA608016

Methods Mentioned

BETA
PCR
bronchoalveolar lavage

Software Mentioned

LefSe
mothur

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