Fecal microbiota transplantation: a promising strategy in preventing the progression of non-alcoholic steatohepatitis and improving the anti-cancer immune response

Expert Opinion on Biological Therapy
Vaihere DelauneChristian Toso

Abstract

Non-alcoholic fatty liver disease (NAFLD) has the potential to progress to hepatocellular carcinoma (HCC). However, limited therapies are currently available for the treatment of advanced HCC, and one must strive to search for novel strategies. Areas covered: We provide insight on current knowledge related to gut microbiota and NAFLD, summarize the sequence linking obesity to HCC and highlight gut dysbiosis in obesity and its consequences on the liver. We detail the impact of the gut microbiota on immune checkpoint inhibitors, and speculate on the role of fecal microbiota transplantation (FMT) in NAFLD and in improving anti-neoplastic immune response. Expert Opinion: Manipulation of the gut microbiota seems promising in the secondary prevention of NAFLD/NASH and/or in potentiating anti-cancer immune response, notably by a global 'resetting' using FMT. However, the composition of a 'harmful' gut microbiome in HCC still needs to be characterized, and the impact of FMT on HCC growth needs to be assessed.

References

Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P Nolan
Oct 25, 2000·Journal of Pediatric Gastroenterology and Nutrition·P GuptaS Guandalini
Dec 18, 2001·Nutrition·U N Das
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Grace L Su
Mar 19, 2003·Journal of Clinical Gastroenterology·Henrik Toft SørensenHendrik Vilstrup
Sep 11, 2004·Immunity·Tsvetelina Pentcheva-HoangJames P Allison
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shuang FuJonathan S Bromberg
Jun 30, 2005·The American Journal of Gastroenterology·Rodrigo BibiloniR Balfour Sartor
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Oct 7, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paola BrunDiego Martines
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Feb 29, 2008·Cytokine·Yong-Chen LuPamela S Ohashi
Sep 10, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S H DuncanH J Flint
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Jun 6, 2009·Obesity·Andreas SchwiertzPhilip D Hardt
Aug 13, 2009·Journal of Gastroenterology·Natsuko KawadaYasuhiko Tomita
Sep 29, 2009·Nature Immunology·Brian T FifeJeffrey A Bluestone
Nov 17, 2009·QJM : Monthly Journal of the Association of Physicians·J K DowmanP N Newsome
Feb 4, 2010·Journal of Clinical Immunology·Christoph Blaschitz, Manuela Raffatellu
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Feng ShiFu-Sheng Wang
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Apr 8, 2011·World Journal of Gastroenterology : WJG·Roberto Berni CananiAntonio Calignano
May 6, 2011·The American Journal of Clinical Nutrition·Reiner JumpertzJonathan Krakoff
Oct 14, 2011·Journal of Clinical Gastroenterology·Lawrence J Brandt, Sheela S Reddy
Dec 20, 2011·Seminars in Immunology·Michael J MolloyYasmine Belkaid
Apr 21, 2012·Cancer Cell·Dianne H DapitoRobert F Schwabe
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Oct 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lixin ZhuSteven R Gill
Oct 23, 2012·Nutrition Research·Tatiana F S TeixeiraMaria do Carmo G Peluzio
Feb 26, 2013·Nature Reviews. Microbiology·Felix Sommer, Fredrik Bäckhed
Mar 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Maitreyi RamanKevin P Rioux
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Aug 28, 2013·Journal of Hepatology·Jessica DysonHelen L Reeves
Sep 21, 2013·Nature Immunology·Craig N Jenne, Paul Kubes
Nov 5, 2013·Nature Reviews. Gastroenterology & Hepatology·Katrina Ray
Apr 1, 2014·Cell·Yasmine Belkaid, Timothy W Hand

❮ Previous
Next ❯

Citations

Jul 13, 2019·Nature Reviews. Gastroenterology & Hepatology·Mary Ellen SandersRobert A Rastall
Jan 9, 2019·Frontiers in Physiology·David PorrasSonia Sánchez-Campos
Dec 11, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Faridoddin MirshahiMasoud H Manjili
May 13, 2020·Journal of Clinical Medicine·Paula IruzubietaFernando de la Cruz
Aug 28, 2020·Frontiers in Medicine·Xiaofan JiangXin Guo
May 8, 2021·Therapeutic Advances in Gastroenterology·Devvrat Yadav, Sahil Khanna
Jul 3, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Manisha GuptaOnkar Bedi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Toshifumi WakaiKatsuyoshi Hatakeyama
Nihon rinsho. Japanese journal of clinical medicine
Keisuke OeToshiji Saibara
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Z M Younossi
Medical Sciences : Open Access Journal
Sanjoy RoychowdhuryGail A M Cresci
© 2022 Meta ULC. All rights reserved