Fecal microbiota transplantation for refractory Crohn's disease

Intestinal research
Seon Ho BakYoung-Seok Cho

Abstract

Approximately one-third of patients with Crohn's disease do not respond to conventional treatments, and some experience significant adverse effects, such as serious infections and lymphoma, and many patients require surgery due to complications. Increasing evidence suggests that specific changes in the composition of gut microbiota, termed as dysbiosis, are a common feature in patients with inflammatory bowel disease (IBD). Dysbiosis can lead to activation of the mucosal immune system, resulting in chronic inflammation and the development of mucosal lesions. Recently, fecal microbiota transplantation, aimed at modifying the composition of gut microbiota to overcome dysbiosis, has become a potential alternative therapeutic option for IBD. Herein, we present a patient with Crohn's colitis in whom biologic therapy failed previously, but clinical remission and endoscopic improvement was achieved after a single fecal microbiota transplantation infusion.

References

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Citations

Mar 8, 2019·International Journal of Food Sciences and Nutrition·E Salvucci
Nov 8, 2018·Gut and Liver·Jung Hoon Song, You Sun Kim
Aug 26, 2020·JAAPA : Official Journal of the American Academy of Physician Assistants·Miranda Collins, Morgan DeWitt
Mar 8, 2019·Nature Medicine·Beth A HelminkJennifer A Wargo
Jul 16, 2020·Soa--chʻŏngsonyŏn Chŏngsin Ŭihak = Journal of Child & Adolescent Psychiatry·Mira KimTae Won Park
Apr 25, 2018·Protein & Cell·Faming ZhangUNKNOWN FMT-standardization Study Group
Aug 22, 2020·World Journal of Gastroenterology : WJG·Yezaz A GhouriBo Shen
Jul 16, 2020·Soa--chʻŏngsonyŏn Chŏngsin Ŭihak = Journal of Child & Adolescent Psychiatry·Donghun Oh, Keun-Ah Cheon
Jul 29, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel

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Methods Mentioned

BETA
surgical resection
biopsy

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Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.