Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor

Journal of Clinical Medicine
Stefano BibbòAntonio Gasbarrini

Abstract

In the past decade, fecal microbiota transplantation (FMT) has rapidly spread worldwide in clinical practice as a highly effective treatment option against recurrent Clostridioides difficile infection. Moreover, new evidence also supports a role for FMT in other conditions, such as inflammatory bowel disease, functional gastrointestinal disorders, or metabolic disorders. Recently, some studies have identified specific microbial characteristics associated with clinical improvement after FMT, in different disorders, paving the way for a microbiota-based precision medicine approach. Moreover, donor screening has become increasingly more complex over years, along with standardization of FMT and the increasing number of stool banks. In this narrative review, we discuss most recent evidence on the screening and selection of the stool donor, with reference to recent studies that have identified specific microbiological features for clinical conditions such as Clostridioides difficile infection, irritable bowel syndrome, inflammatory bowel disease, and metabolic disorders.

References

Jun 29, 2004·Journal of Clinical Gastroenterology·Thomas J BorodySteven Siarakas
Oct 10, 2008·Advances in Experimental Medicine and Biology·Vincent B Young, Thomas M Schmidt
May 19, 2012·Trends in Microbiology·Robert A Britton, Vincent B Young
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Jan 18, 2013·The New England Journal of Medicine·Els van NoodJosbert J Keller
Feb 27, 2013·The American Journal of Gastroenterology·Christina M SurawiczBrian S Zuckerbraun
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S B DebastUNKNOWN European Society of Clinical Microbiology and Infectious Diseases
Nov 29, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alexa R WeingardenAlexander Khoruts
Jul 6, 2014·Journal of Immunology Research·Stefano BibbòGiovanni Cammarota
Oct 17, 2014·JAMA : the Journal of the American Medical Association·Ilan YoungsterElizabeth L Hohmann
Jan 7, 2015·Pharmacology & Therapeutics·Giovanni CammarotaDiego Currò
Apr 16, 2015·The New England Journal of Medicine·Daniel A Leffler, J Thomas Lamont
Sep 5, 2015·Gut·Julian R MarchesiAilsa Hart
Nov 1, 2015·Journal of Crohn's & Colitis·Severine VermeireJeroen Raes
Dec 24, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Carolyn EdelsteinZain Kassam
Mar 18, 2016·Expert Review of Molecular Diagnostics·Yuliya Zboromyrska, Jordi Vila
Jun 12, 2016·Microbes and Infection·Jean-Marc Cavaillon, Sandra Legout
Aug 17, 2016·PloS One·Sinan WangBangmao Wang
Oct 16, 2016·Journal of Clinical Gastroenterology·Giovanni GasbarriniAnnagiulia Gramenzi
Jan 15, 2017·Gut·Giovanni CammarotaUNKNOWN European FMT Working Group
May 17, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B K DeckerT N Palmore
Nov 23, 2017·Frontiers in Immunology·Floris FransenPaul de Vos
Feb 17, 2018·Nature Reviews. Drug Discovery·Asher Mullard
Feb 23, 2018·Journal of Pediatric Gastroenterology and Nutrition·Danielle BarnesK T Park
Mar 22, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L Clifford McDonaldMark H Wilcox
May 24, 2018·Microbiome·Concetta PanebiancoValerio Pazienza

❮ Previous
Next ❯

Citations

Aug 14, 2020·Journal of Clinical Medicine·Abraham AjayiStella Smith
Jan 27, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Carlo Romano SettanniAntonio Gasbarrini
Aug 18, 2020·Anaerobe·Asma Gasmi BenahmedGeir Bjørklund
May 1, 2021·Journal of Personalized Medicine·Alfredo CesarioGiovanni Scambia
Jul 3, 2021·International Journal of Molecular Sciences·Ting-Wei Kao, Chin-Chou Huang
Jun 26, 2021·World Journal of Gastroenterology : WJG·Magdy El-SalhySutep Gonlachanvit
Jul 9, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Magdy El-SalhyJan Gunnar Hatlebakk
Oct 14, 2021·Seminars in Immunopathology·Loreto GesualdoRosanna Coppo
Nov 2, 2021·Frontiers in Microbiology·Yifan ZhongHaifeng Wang
Dec 25, 2021·Journal of the Pediatric Infectious Diseases Society·Michael A Silverman, Jamal L Green
Feb 8, 2022·Microbiome·Torben KuehnastAlexander Mahnert

❮ Previous
Next ❯

Methods Mentioned

BETA
gastric bypass

Related Concepts

Related Feeds

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.