Fecal selenium excretion is regulated by dietary selenium intake.

Biological Trace Element Research
Lucia F C PedrosaRaymond F Burk

Abstract

Whole-body selenium is regulated by excretion of the element. Reports of studies carried out using isotopic tracers have led to the conclusion that urinary selenium excretion is regulated by selenium intake but that fecal excretion is not. Because of the limitations of tracer studies, we measured urinary and fecal selenium excretion by mice with selenium intakes in the form of sodium selenite ranging from deficient to almost toxic. Tissue and whole-body selenium concentrations increased sharply between deficient and adequate selenium intakes, reflecting tissue accumulation of selenium in the form of selenoproteins. Once the requirement for selenium had been satisfied, a 31-fold further increase in intake resulted in less than doubling of tissue and whole-body selenium, demonstrating the effectiveness of selenium excretion by the mouse. Urinary selenium excretion increased with increases in dietary selenium intake. Fecal selenium excretion, which was 20 to 30 % of the selenium excreted in the physiological range, responded to moderately high selenium intake but did not increase further when selenium intake was increased to even higher levels. Thus, fecal selenium excretion contributes to regulation of whole-body selenium at phys...Continue Reading

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Citations

Apr 4, 2015·Nutrients·Gerald F Combs
Aug 19, 2015·Biological Trace Element Research·Mengyao GuoGanzhen Deng
May 15, 2015·Annual Review of Nutrition·Raymond F Burk, Kristina E Hill
Dec 7, 2019·Metallomics : Integrated Biometal Science·Kazuaki Takahashi, Yasumitsu Ogra
May 7, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasumitsu Ogra, Kazuaki Takahashi
Aug 13, 2021·Environmental Science & Technology·Chantal M LanctôtWilliam W Bennett

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