Fecal Transplantation for Clostridium Difficile-"All Stool May Not Be Created Equal"

Journal of the International Association of Providers of AIDS Care
Joseph C GatheJohn B Clemmons

Abstract

Clostridium difficile is a gram-positive bacterium that is recognized as a causative organism of pseudomembranous enterocolitis. This infection has become a major public health challenge and is a source of considerable morbidity and mortality in those infected. We present a 62-year-old African American female with a long history of HIV infection, who presented with abdominal pain and continuous diarrhea due to pseudomembranous colitis. After failing multiple episodes of conventional therapy, it was decided to treat her with fecal microbiota transplantation. Fecal microbiota transplantation was given on 3 separate occasions from a biological-related donor without success. It was only after a fourth transplant was done with a nonrelated donor that the patient resolved her diarrhea within 48 hours. We suggest that fecal samples from different donors have different abilities to cure Clostridium difficile colitis in at least this immunosuppressed patient.

References

Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Travis H SanchezUNKNOWN Adult/Adolescent Spectrum of HIV Disease Study Group
Feb 27, 2013·The American Journal of Gastroenterology·Christina M SurawiczBrian S Zuckerbraun
Mar 21, 2013·The American Journal of Gastroenterology·Zain KassamRichard H Hunt
May 6, 2015·Annals of Internal Medicine·Dimitri DrekonjaTimothy J Wilt

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Citations

Sep 25, 2018·Canadian Journal of Gastroenterology & Hepatology·Oluwaseun ShogbesanAnthony Donato
Dec 4, 2020·Current Opinion in Pharmacology·Cecilia Rosel-PechSandra Pinto-Cardoso
May 4, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Damani A Piggott, Susan Tuddenham

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Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

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