Feed contaminated with Fusarium toxins alter lymphocyte proliferation and apoptosis in primiparous sows during the perinatal period

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T Malovrh, B Jakovac-Strajn

Abstract

Two groups of pregnant primiparous sows (day 89 ± 2 of gestation) were 54 days (± 1 day) fed either with an experimental diet (5.08 mg kg(-1) deoxynivalenol--DON, 0.09 mg kg(-1) zearalenone and 21.61 mg kg(-1) fusaric acid) or control diet (0.25 mg kg(-1) DON). The consummation of feed was significantly higher in the control group. Lymphocyte stimulation in culture from peripheral blood lymphocytes (PBL) was measured by BrdU incorporation test using two different concentrations of mitogen PHA 10 and 20 μg ml(-1), two different concentrations of DON (5 and 1 μg ml(-1)) and a combination of both, PHA and DON (PHA 10+DON 5, PHA 10+DON 1 and PHA 10+DON 0.1 μg ml(-1)). The lymphocyte proliferation, except for PHA 10 μg ml(-1), was significantly higher in the experimental group. Further on, using the photometric enzyme immunoassay, the apoptosis was studied in non-stimulated 72h lymphocyte culture or stimulated with 1 μg ml(-1) of DON. The significantly higher apoptosis was in non-stimulated lymphocyte cultures from the experimental group (P = 0.036). The results suggest that such feed may affect the peripheral lymphocyte population in the direction of their proliferation response and programmed cell death.

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Citations

Mar 22, 2013·Archives of Toxicology·Kashif Jilani, Florian Lang
May 31, 2012·Archives of Animal Nutrition·Annabella Khol-ParisiniJürgen Zenteke
Jul 28, 2011·Toxicology and Applied Pharmacology·Constanze PietschPatricia Burkhardt-Holm
Dec 4, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Juliana R GerezAna Paula F L Bracarense
Nov 15, 2013·Molecular and Cellular Probes·Stefan BugovskyGünter Allmaier
Jul 9, 2016·Toxicon : Official Journal of the International Society on Toxinology·Naeem Sheik AbdulAnil A Chuturgoon
Nov 30, 2019·Toxicon : Official Journal of the International Society on Toxinology·Naeem Sheik AbdulAnil A Chuturgoon
Sep 3, 2020·Acta Veterinaria Hungarica·Igor Ujčič-VrhovnikBreda Jakovac-Strajn

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis