Feed-forward neural networks using cerebral MR spectroscopy and DTI might predict neurodevelopmental outcome in preterm neonates.

European Radiology
T JanjicE R Gizewski

Abstract

We aimed to evaluate the ability of feed-forward neural networks (fNNs) to predict the neurodevelopmental outcome (NDO) of very preterm neonates (VPIs) at 12 months corrected age by using biomarkers of cerebral MR proton spectroscopy (1H-MRS) and diffusion tensor imaging (DTI) at term-equivalent age (TEA). In this prospective study, 300 VPIs born before 32 gestational weeks received an MRI scan at TEA between September 2013 and December 2017. Due to missing or poor-quality spectroscopy data and missing neurodevelopmental tests, 173 VPIs were excluded. Data sets consisting of 103 and 115 VPIs were considered for prediction of motor and cognitive developmental delay, respectively. Five metabolite ratios and two DTI characteristics in six different areas of the brain were evaluated. A feature selection algorithm was developed for receiving a subset of characteristics prevalent for the VPIs with a developmental delay. Finally, the predictors were constructed employing multiple fNNs and fourfold cross-validation. By employing the constructed fNN predictors, we were able to predict cognitive delays of VPIs with 85.7% sensitivity, 100% specificity, 100% positive predictive value (PPV) and 99.1% negative predictive value (NPV). For the...Continue Reading

References

Jan 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Mori, P C van Zijl
Oct 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R KreisB D Ross
Dec 1, 1996·Radiology·C PierpaoliG Di Chiro
Oct 20, 1998·Seminars in Pediatric Neurology·H C Kinney, S A Back
Aug 8, 2002·Magnetic Resonance Imaging·Saïd BoujrafMichel Osteaux
Dec 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R KreisP S Hüppi
Mar 3, 2005·Pediatrics·Susan R HintzUNKNOWN NICHD Neonatal Research Network
Mar 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Art RiddleStephen A Back
Jun 30, 2006·Mental Retardation and Developmental Disabilities Research Reviews·Stephen A Back
Aug 18, 2006·The New England Journal of Medicine·Lianne J WoodwardTerrie E Inder
Feb 6, 2007·Progress in Neurobiology·John R MoffettAryan M A Namboodiri
Jun 16, 2007·AJNR. American Journal of Neuroradiology·A I BarthaD M Ferriero
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Aug 22, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Dimitry S A NuytenMarc J van de Vijver
Apr 22, 2009·Pediatric Neurology·Erika BrighinaMario Rango
May 23, 2009·Developmental Medicine and Child Neurology·Jessica RoseDavid K Stevenson
May 11, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Heidi M FeldmanShayna Gaman-Bean
Mar 10, 2011·Pediatric Research·Laura BassiSerena J Counsell
Feb 28, 2013·Developmental Medicine and Child Neurology·Francisca T De BruïneJeroen Van Der Grond
Apr 27, 2013·AJNR. American Journal of Neuroradiology·H KidokoroT E Inder
Oct 10, 2013·Developmental Medicine and Child Neurology·Kerstin PannekStephen E Rose
Jul 30, 2014·Pediatrics·Hiroyuki KidokoroTerrie E Inder
Nov 5, 2016·Frontiers in Pediatrics·Krishna Revanna GopagondanahalliAtul Malhotra
May 24, 2017·Acta Neuropathologica·Stephen A Back
Aug 12, 2017·Journal of Pathology and Translational Medicine·Young Ah Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Impax EE
jMRUI
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.