Feedback from network states generates variability in a probabilistic olfactory circuit

Cell
Andrew GordusCornelia I Bargmann

Abstract

Variability is a prominent feature of behavior and is an active element of certain behavioral strategies. To understand how neuronal circuits control variability, we examined the propagation of sensory information in a chemotaxis circuit of C. elegans where discrete sensory inputs can drive a probabilistic behavioral response. Olfactory neurons respond to odor stimuli with rapid and reliable changes in activity, but downstream AIB interneurons respond with a probabilistic delay. The interneuron response to odor depends on the collective activity of multiple neurons-AIB, RIM, and AVA-when the odor stimulus arrives. Certain activity states of the network correlate with reliable responses to odor stimuli. Artificially generating these activity states by modifying neuronal activity increases the reliability of odor responses in interneurons and the reliability of the behavioral response to odor. The integration of sensory information with network states may represent a general mechanism for generating variability in behavior.

References

Feb 15, 1979·Nature·P G Lillywhite, S B Laughlin
Apr 1, 1976·Theoretical Population Biology·E L Charnov
Jan 1, 1987·Annual Review of Biophysics and Biophysical Chemistry·W Bialek
Dec 5, 1974·Journal of Molecular Biology·H F EpsteinS Brenner
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J J Hopfield
May 25, 2004·Nature Neuroscience·Wu LiCharles D Gilbert
Feb 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jesse M GrayCornelia I Bargmann
Apr 14, 2005·PLoS Biology·Bence P OlveczkyMichale S Fee
Sep 15, 2006·Journal of Neurophysiology·Michael A SilverDavid J Heeger
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, Martin Chalfie
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Damon A ClarkAravinthan D T Samuel
May 13, 1983·Science·S KirkpatrickM P Vecchi
Jul 1, 2008·Nature Neuroscience·Jerry E MellemAndres V Maricq
Nov 10, 2009·Nature Methods·Zengcai V GuoSharad Ramanathan
Jan 26, 2010·Journal of Neuroscience Methods·Juliette Ben ArousWilliam R Schafer
Feb 16, 2010·Nature Neuroscience·Gaby MaimonMichael H Dickinson
Feb 26, 2010·Journal of Neurophysiology·Nikolai C DembrowHarold H Zakon
Mar 2, 2010·Neuron·Cristopher M Niell, Michael P Stryker
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Kanaka RajanHaim Sompolinsky
Feb 10, 2011·PLoS Computational Biology·Lav R VarshneyDmitri B Chklovskii
Jul 8, 2011·Journal of Neurophysiology·Timothy L WarrenMichael S Brainard
Jul 27, 2011·Behavioral Neuroscience·Donald E FrederickLeslie M Kay
Nov 12, 1986·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J G WhiteS Brenner
Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jasper AkerboomLoren L Looger
Sep 10, 2013·Nature Neuroscience·Sarah G Leinwand, Sreekanth H Chalasani
Sep 10, 2013·Nature Methods·Tina SchrödelAlipasha Vaziri
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Johannes LarschDirk R Albrecht
Feb 11, 2014·Nature Methods·Nathan C KlapoetkeEdward S Boyden
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Navin PokalaCornelia I Bargmann
May 20, 2014·Nature Methods·Robert PrevedelAlipasha Vaziri
Sep 5, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kris S ChaisanguanthumPhilip N Sabes

❮ Previous
Next ❯

Citations

Dec 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey P NguyenAndrew M Leifer
Oct 27, 2015·Cell·Kristin Branson, Jeremy Freeman
Apr 11, 2015·Cell·William B Kristan
Aug 5, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christopher Fang-YenAravinthan D T Samuel
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Andrew B Barron, Colin Klein
May 5, 2016·Nature·Meital Oren-SuissaOliver Hobert
Jun 24, 2016·Current Opinion in Neurobiology·Eduardo J Izquierdo, Randall D Beer
Jul 12, 2016·Neuron·Carlos PantojaEhud Y Isacoff
Sep 2, 2016·Journal of the Royal Society, Interface·Alex Gomez-MarinAndré E X Brown
Sep 27, 2016·Current Opinion in Neurobiology·Sophie Rengarajan, Elissa A Hallem
Sep 9, 2016·PLoS Computational Biology·Aharon AzulayAlon Zaslaver
Feb 28, 2018·Nature Chemical Biology·Kiryl D PiatkevichEdward S Boyden
Apr 11, 2015·Nature Reviews. Neuroscience·Fiona Carr
May 1, 2019·Cellular and Molecular Life Sciences : CMLS·Ardalan HendiKota Mizumoto
Sep 12, 2019·Nature Communications·Wagner Steuer CostaAlexander Gottschalk
Jul 7, 2017·Biological Theory·J H van Hateren
Mar 30, 2018·The Journal of Experimental Biology·Timothy L WarrenMichael H Dickinson
Sep 12, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Harris S KaplanManuel Zimmer
Aug 23, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Samantha Hughes, Tansu Celikel
Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Muneki IkedaIkue Mori
Nov 14, 2019·ELife·May DobosiewiczCornelia I Bargmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

BRAIN Initiative Cell Census Network (BICCN)

The BRAIN Initiative Cell Census Network aims to identify and provide experimental access to the different brain cell types to determine their roles in health and disease. Discover the latest research from researchers in the BRAIN Initiative Cell Census Network here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.