PMID: 6159085Jul 1, 1980Paper

Feedback inhibition of hepatic DNA synthesis

Cell and Tissue Kinetics
R Schulte-Hermann, E Schmitz

Abstract

alpha-Hexachlorocyclohexane (alpha-HCH) and some other xenobiotic inducers were used to elicit adaptive increases in mono-oxygenase activity, size and DNA content of rat liver. After elimination of the inducers, organ size and mono-oxygenase activity returned to normal whereas the DNA content of the liver remained increased. Upon renewed treatment with an inducer the adaptive responses uncoupled. While mono-oxygenase induction and liver enlargement did occur, DNA replication was largely suppressed. These findings show that in the hyperplastic state the liver is resistant to stimulation of DNA synthesis by the inducers. It is concluded that the DNA content of the liver (or the number of liver cells) is controlled by a feedback system which monitors an excess of DNA (cells) and suppresses cell replication if the content of DNA exceeds the normal level. Organ mass has little, if any, effect on the operation of this feedback system.

References

Feb 1, 1975·Life Sciences·W S Bullough
May 26, 1976·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C NadalF Zajdela
Feb 1, 1977·Journal of Cellular Physiology·D M StoccoM A Wilson
May 15, 1977·Biochemical Pharmacology·W G LevineL A Stocken
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·R Schulte-HermannW Koransky
May 15, 1973·FEBS Letters·J C Houck, H Hennings
Dec 1, 1967·Experimental and Molecular Pathology·C J EpsteinM M Garrison
Sep 1, 1974·CRC Critical Reviews in Toxicology·R Schulte-Hermann
Dec 1, 1971·Comparative Biochemistry and Physiology. A, Comparative Physiology·R M EvansP Mongin
Nov 1, 1972·Transplantation·T J Van VroonhovenR A Malt
Sep 1, 1953·The Biochemical Journal·M F HARRISON
Jul 1, 1958·The Journal of Endocrinology·G C KENNEDYD M PARROTT

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Citations

Aug 1, 1992·Journal of Applied Toxicology : JAT·D PalutJ Szlezak-Kopeć
Apr 1, 1983·Environmental Health Perspectives·R Schulte-HermannH Berger
Feb 1, 1982·Toxicologic Pathology·R Schulte-HermannJ Schuppler
Jan 1, 1986·Toxicologic Pathology·C Nadal

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