PMID: 39187May 1, 1979

Feedback regulation of nephron filtration rate during pharmacologic interference with the renin-angiotensin and adrenergic systems in rats

Kidney International
N StoweM Hermle


Tubuloglomerular feedback has been defined as a mechanism in which changes in distal tubular sodium chloride delivery induce changes in glomerular arteriolar resistance. Experiments were performed in rats to test the hypothesis that the alterations in vasomotor activity are controlled by local hormonal mechanisms. Early proximal flow rate (EPFR), used as an index of filtration rate, was assessed at loop perfusion rates of 10 and 40 nl/min and during zero loop flow before and during intravenous administration of agents which interfere with the reninangiotensin or adrenergic systems. During infusion of the angiotensin (A) antagonists [Sar1,Ile8-]-AII or [Me2,Gly1,Ile8]-AII at doses ranging from 4.8 to 30.6 micrograms/kg . min, feedback response, expressed as percent change of EPFR during loop flow elevation from 3 to 40 nl/min, fell from a mean of 47.6 +/- 3.3% to 33.2 +/- 2.9% (P less than 0.05). Likewise, after administration of the converting enzyme inhibitor SQ 20881 in a dose ranging between 5.5 and 34.0 mg/kg, feedback response decreased from 48.5 +/- 2.1% to 25.9 +/- 1.9% (P less than 0.001) and returned to 43.1 +/- 5.1% after the inhibitory effect of SQ 20881 on the pressure response to angiotensin I had disappeared. Lumi...Continue Reading


Aug 12, 1975·Pflügers Archiv : European journal of physiology·J SchnermannH Dahlheim
Dec 1, 1980·Pflügers Archiv : European journal of physiology·B J Tucker, R C Blantz
Aug 1, 1989·Baillière's Clinical Endocrinology and Metabolism·K D Mitchell, L G Navar
Mar 1, 1983·Acta Physiologica Scandinavica·P P Leyssac, L Baumbach
Sep 5, 2002·Annual Review of Physiology·J Schnermann, David Z Levine
Nov 1, 1979·The Journal of Clinical Investigation·D W PlothL G Navar
Oct 1, 1980·Klinische Wochenschrift·R C Blantz
Jan 5, 2002·The Journal of Physiology·Armin JustHartmut R Kirchheim
Oct 1, 1991·Kidney International·I Ichikawi, R C Harris
May 1, 1984·Kidney International·R C Blantz, J C Pelayo
May 1, 1991·Microvascular Research·M S DietrichM Steinhausen
Jan 1, 1981·Pharmacology & Therapeutics·P C Weber, W Siess
Feb 1, 1981·Circulation Research·N R LevensR M Carey
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher S Wilcox
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Armin Just
Feb 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Reetu R SinghKate M Denton
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Sep 16, 1985·Klinische Wochenschrift·K O Stumpe
Mar 5, 1998·The American Journal of Physiology·J Schnermann
May 18, 1999·The American Journal of Physiology·T TraynorJ Schnermann
Jan 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Pouneh NouriWilliam J Welch


Oct 1, 1976·Canadian Journal of Physiology and Pharmacology·M C Carrara, A D Baines
Mar 15, 1976·The Biochemical Journal·B J Morris, C I Johnston
May 6, 1977·Pflügers Archiv : European journal of physiology·J SchnermannM Hermle
Oct 1, 1977·Kidney International·D W PlothE Schmidmeier
Aug 12, 1975·Pflügers Archiv : European journal of physiology·J Schnermann, M Hermle
Apr 6, 1976·Pflügers Archiv : European journal of physiology·J SchnermannM Hermle
Aug 12, 1975·Pflügers Archiv : European journal of physiology·J SchnermannH Dahlheim
Aug 29, 1975·Pflügers Archiv : European journal of physiology·T Morgan, J M Davis
Aug 29, 1975·Pflügers Archiv : European journal of physiology·R Müller-SuurK Hierholzer
Mar 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·D J GoldsteinC Fischer-Ferraro
Oct 1, 1972·The Journal of Endocrinology·B LeckieG McElwee
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J A GagnonW Flamenbaum
Feb 1, 1967·British Journal of Pharmacology and Chemotherapy·R G Shanks
Mar 1, 1972·European Journal of Pharmacology·I A ReidW F Ganong
Jan 1, 1974·Pflügers Archiv : European journal of physiology·K HierholzerI Lichtenstein
Jan 1, 1973·Annual Review of Pharmacology·H Thoenen, J P Tranzer
Jun 1, 1974·The Journal of Clinical Investigation·F S Wright, J Schnermann
Jul 1, 1972·Circulation Research·J C McGiffA J Lonigro
Jan 1, 1970·Pflügers Archiv : European journal of physiology·J SchnermannG Grill
Feb 1, 1974·The Journal of Clinical Investigation·L G NavarJ R Clapp
May 1, 1964·The American Journal of Medicine·K THURAU

Related Concepts

Enzyme Inhibitor Drugs
Renin-Angiotensin Pathway
Diastolic Blood Pressure
Catecholamines Measurement
Renal Glomerular Disease
Renal Tubule Structure
Adrenergic alpha-Antagonists
Angiotensin I Assay

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.