PMID: 2111172May 1, 1990Paper

Feedback regulation of platelet function by 12S-hydroxyeicosatetraenoic acid: inhibition of arachidonic acid liberation from phospholipids

Biochimica Et Biophysica Acta
F SekiyaY Saito

Abstract

We have proposed a mechanism that platelet aggregation is regulated by its 12-lipoxygenase product, 12S-hydroxyeicosatetraenoic acid (12-HETE) (Sekiya, F., Takagi, J. and Saito, Y. (1989) Thrombos. Res. 56, 407-415). Inhibition of endogenous 12-HETE production by 15-HETE, a specific inhibitor of 12-lipoxygenase, accelerated aggregation of bovine platelets in response to collagen and arachidonic acid liberation from phospholipids was enhanced. Exogenously added 12-HETE suppressed collagen-induced liberation of arachidonic acid and the aggregation was also inhibited. On the other hand, 12-HETE did not interfere with thromboxane synthesis from free arachidonic acid in a cell-free system. These observations suggest that 12-HETE exerts a negative feedback to prevent excess aggregation through interference with arachidonic acid liberation from membrane phospholipids.

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Citations

Oct 29, 2014·Journal of Inflammation·Benjamin H MaskreyPhillip D Whitfield
Aug 30, 1991·Biochemical and Biophysical Research Communications·F SekiyaY Saito
Apr 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Benedetta PorroViviana Cavalca
Sep 17, 2015·Advances in Nutrition·Melissa GabbsHarold M Aukema
May 22, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jennifer YeungMichael Holinstat
Aug 13, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie P B CaligiuriHarold M Aukema
Oct 11, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P CluttonJ E Freedman

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