PMID: 7012833Dec 1, 1980Paper

Feedback regulation of ribosomal protein gene expression in Escherichia coli: structural homology of ribosomal RNA and ribosomal protein MRNA

Proceedings of the National Academy of Sciences of the United States of America
M NomuraL E Post

Abstract

Certain ribosomal proteins (r proteins) in Escherichia coli, such as S4 and S7, function as feedback repressors in the regulation of r-protein synthesis. These proteins inhibit the translation of their own mRNA. The repressor r proteins so far identified are also known to bind specifically to rRNA at an initial stage in ribosome assembly. We have found structural homology between the S7 binding region on 16S rRNA and a region of the mRNA where S7 acts as a translational repressor. Similarly, there is structural homology between one of the reported S4 binding regions on 16S rRNA and the mRNA target site for S4. The observed homology supports the concept that regulation by repressor r proteins is based on competition between rRNA and mRNA for these proteins and that the same structural features and of the r proteins are used in their interactions with both rRNA and mRNA.

References

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Citations

Jan 1, 1981·Molecular & General Genetics : MGG·H Lang-Yang, G Zubay
Jan 1, 1981·Molecular & General Genetics : MGG·A Böck
Jan 1, 1993·Molecular & General Genetics : MGG·D Zhuo, L Bonen
Jan 1, 1984·Molecular & General Genetics : MGG·M IwamiS Osawa
Jan 1, 1983·Molecular & General Genetics : MGG·N Tomioka, M Sugiura
Jan 1, 1984·Molecular & General Genetics : MGG·R TakataK Hori
Jan 1, 1985·Molecular & General Genetics : MGG·G RallingT Linn
Jan 1, 1982·Molecular & General Genetics : MGG·R TakataT Mukai
Mar 8, 2005·Archives of Microbiology·Wade C Winkler
Jan 1, 1982·Progress in Biophysics and Molecular Biology·A Liljas
Jan 1, 1983·Bio Systems·G A King
Jul 20, 2002·Journal of Molecular Biology·Alexander SerganovChantal Ehresmann
Mar 5, 2003·Trends in Genetics : TIG·Pascale Romby, Mathias Springer
Nov 30, 2002·Biochimie·Michael WorbsJanice M Zengel
Dec 3, 1981·Nature·L HudsonA Landy
Apr 21, 2009·Nature Structural & Molecular Biology·Ming C HammondRonald R Breaker
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R L GourseR A Zimmermann
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·N RobakisH Weissbach
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D Schindler, H Echols
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D A WinkelmannJ A Lake
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G Baughman, M Nomura
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Aug 5, 2009·Briefings in Functional Genomics & Proteomics·Magali Naville, Daniel Gautheret
Mar 31, 2010·Briefings in Functional Genomics·Magali Naville, Danie Gautheret

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