Feedback stimulation of somatodendritic serotonin release: a 5-HT3 receptor-mediated effect in the raphe nuclei of the rat

Brain Research Bulletin
E BagdyL G Harsing

Abstract

Slices from rat midbrain containing the raphe nuclei and from hippocampus were prepared, loaded with [3H]5-HT and superfused and the resting and the electrically stimulated [3H]5-HT release was measured. The 5-HT3 receptor agonist 2-methyl-5-HT (1 to 10 micromol/l) increased the resting tritium outflow in superfused raphe nuclei slices, EC50 5.3 micromol/l. The 2-methyl-5-HT-induced increase of tritium outflow was an external Ca2+-independent process and was not altered by reserpine pretreatment but it was reversed by addition of the 5-HT uptake inhibitor fluoxetine (1 micromol/l). The 5-HT3 receptor antagonists ondansetron and GYKI-46 903 (1 micromol/l) did not antagonize the stimulatory effect of 2-methyl-5-HT on resting tritium outflow. 2-Methyl-5-HT in lower concentration increased the electrically induced tritium overflow from raphe nuclei slices (EC50 0.56 micromol/l) and also from hippocampal slices preloaded with [3H]5-HT. These effects were reversed by 1 micromol/l of ondansetron and GYKI-46903. The 5-HT3 receptor antagonists (1 micromol/l) were without effects on depolarization-evoked [3H]5-HT release at 2 Hz stimulation, when 10 Hz stimulation was used, ondansetron and GYKI-46 903 reduced the tritium overflow from ra...Continue Reading

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Citations

Nov 9, 2002·Brain Research. Brain Research Reviews·Albert AdellFrancesc Artigas
Jan 4, 2001·Trends in Neurosciences·J A van Hooft, H P Vijverberg
Apr 15, 1999·Annual Review of Neuroscience·A B MacDermottS A Siegelbaum
Jan 23, 2016·Frontiers in Synaptic Neuroscience·Ran YeRandy D Blakely
Feb 26, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jaime M Monti, Héctor Jantos
Mar 16, 2016·Neuroscience and Biobehavioral Reviews·Deepali GuptaMahesh Radhakrishnan
Oct 24, 2012·The International Journal of Neuropsychopharmacology·Cécile BétryNasser Haddjeri
Oct 31, 2002·Human Psychopharmacology·John F. Cryan, Brian E. Leonard
Feb 8, 2005·Medical Hypotheses·Skirmantas Janusonis
Feb 4, 2010·Journal of Psychopharmacology·Ramamoorthy Rajkumar, Radhakrishnan Mahesh
Apr 5, 2011·Sleep Medicine Reviews·Jaime M Monti

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