Feedforward Inhibition Conveys Time-Varying Stimulus Information in a Collision Detection Circuit

Current Biology : CB
Hongxia WangFabrizio Gabbiani

Abstract

Feedforward inhibition is ubiquitous as a motif in the organization of neuronal circuits. During sensory information processing, it is traditionally thought to sharpen the responses and temporal tuning of feedforward excitation onto principal neurons. As it often exhibits complex time-varying activation properties, feedforward inhibition could also convey information used by single neurons to implement dendritic computations on sensory stimulus variables. We investigated this possibility in a collision-detecting neuron of the locust optic lobe that receives both feedforward excitation and inhibition. We identified a small population of neurons mediating feedforward inhibition, with wide visual receptive fields and whose responses depend both on the size and speed of moving stimuli. By studying responses to simulated objects approaching on a collision course, we determined that they jointly encode the angular size of expansion of the stimulus. Feedforward excitation, on the other hand, encodes a function of the angular velocity of expansion and the targeted collision-detecting neuron combines these two variables non-linearly in its firing output. Thus, feedforward inhibition actively contributes to the detailed firing-rate time ...Continue Reading

References

Mar 6, 1975·Nature·M O'Shea, C H Rowell
Feb 1, 1996·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·A C James, D Osorio
Oct 14, 1998·Trends in Genetics : TIG·P PhelanR J Wyman
Jul 20, 2002·Science·Javier Perez-OriveGilles Laurent
Nov 26, 2002·Nature·Fabrizio GabbianiGilles Laurent
Nov 19, 2004·Journal of Neurophysiology·Holger G Krapp, Fabrizio Gabbiani
Dec 23, 2004·The Journal of Physiology·Wolfgang MittmannMichael Häusser
Mar 31, 2005·Neuron·Dawn M Blitz, Wade G Regehr
Jun 2, 2005·Journal of Neurophysiology·Fabrizio GabbianiGilles Laurent
Nov 3, 2005·The European Journal of Neuroscience·Le-Qing WuShu-Rong Wang
Mar 31, 2006·Journal of Neurophysiology·Fabrizio Gabbiani, Holger G Krapp
Mar 31, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas PreussDonald S Faber
Nov 5, 2008·Frontiers in Neuroscience·Juergen Haag, Alexander Borst
Mar 12, 2011·Annual Review of Neuroscience·Haleh Fotowat, Fabrizio Gabbiani
May 7, 2011·Brain, Behavior and Evolution·Yong-Jun LiuBing Li
Oct 25, 2011·Neuron·Jeffry S Isaacson, Massimo Scanziani
Nov 25, 2011·Journal of Neurophysiology·Peter W Jones, Fabrizio Gabbiani
Feb 7, 2012·Current Biology : CB·Saskia E J de Vries, Thomas R Clandinin
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter W Jones, Fabrizio Gabbiani
Nov 23, 2012·Nature·Bilal HaiderMatteo Carandini
Jul 16, 2013·Neuron·John C TuthillMichael B Reiser
Feb 7, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alex S MaussAlexander Borst
Jun 6, 2014·Journal of Neurophysiology·Damián Oliva, Daniel Tomsic
Sep 26, 2014·American Journal of Physiology. Cell Physiology·Rachele SangalettiLaura Bianchi
Dec 17, 2015·Current Biology : CB·Yvette E FisherMarion Silies
Jan 26, 2016·Neuron·Timothy W DunnFilippo Del Bene
Feb 14, 2017·Current Biology : CB·Mehmet F Keleş, Mark A Frye
Jun 24, 2017·Neuron·Catherine R von ReynGwyneth M Card
Nov 10, 2017·Nature·Nathan C KlapoetkeGwyneth M Card

❮ Previous
Next ❯

Citations

Oct 21, 2018·The Journal of Experimental Biology·Tarquin P StottJohn R Gray
Aug 16, 2018·Journal of Neurophysiology·Hongxia WangFabrizio Gabbiani
Feb 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rachel H ParkinsonJohn R Gray
Dec 19, 2020·Neural Networks : the Official Journal of the International Neural Network Society·Lun LiJiaxuan Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.