Feedforward inhibition regulates perirhinal transmission of neocortical inputs to the entorhinal cortex: ultrastructural study in guinea pigs

The Journal of Comparative Neurology
Aline PintoDenis Paré

Abstract

The rhinal cortices constitute the main route for impulse traffic to and from the hippocampus. Tracing studies have revealed that the perirhinal cortex forms strong reciprocal connections with the neo- and entorhinal cortex (EC). However, physiological investigations indicate that perirhinal transmission of neocortical and EC inputs occurs with a low probability. In search of an explanation for these contradictory findings, we have analyzed synaptic connections in this network by combining injections of the anterograde tracer Phaseolus vulgaris-leucoagglutinin (PHAL) into the neocortex, area 36, or area 35 with gamma-aminobutyric acid (GABA) immunocytochemistry and electron microscopic observations. Within area 36, neocortical axon terminals formed only asymmetric synapses, usually with GABA-negative spines (87%), and less frequently with GABA-immunopositive (GABA+) dendrites (13%). A similar synaptic distribution was observed within area 35 except that asymmetric synapses onto GABA+ dendrites were more frequent (23% of synapses). Examination of the projections from area 36 to area 35 and from both regions to the EC revealed an even higher incidence of asymmetric synapses onto GABA+ dendrites (35 and 32%, respectively) than wha...Continue Reading

References

Apr 15, 1977·The Journal of Comparative Neurology·J E Krettek, J L Price
Jun 26, 1992·Brain Research·C M Hughes, A Peters
Mar 15, 1991·The Journal of Comparative Neurology·B A McGuireT N Wiesel
Sep 22, 1986·The Journal of Comparative Neurology·P Room, H J Groenewegen
Sep 22, 1986·The Journal of Comparative Neurology·P Room, H J Groenewegen
Oct 15, 1987·The Journal of Comparative Neurology·R InsaustiW M Cowan
Aug 7, 1989·Brain Research·P GermrothE H Buhl
Oct 1, 1985·Journal of Neurophysiology·D A McCormickD A Prince
Dec 1, 1987·The Journal of Comparative Neurology·L Nitecka, Y Ben-Ari
May 15, 1987·The Journal of Comparative Neurology·P L GabbottD Whitteridge
Oct 1, 1986·The Journal of Comparative Neurology·M P Witter, H J Groenewegen
Jan 1, 1986·Experimental Brain Research·Z F KisvárdayP Somogyi
Nov 1, 1967·Journal of Psychosomatic Research·T J Luparello
Oct 20, 1983·The Journal of Comparative Neurology·T W DeaconK W Eckmann
Dec 22, 1994·The Journal of Comparative Neurology·W A Suzuki, D G Amaral
May 27, 1996·The Journal of Comparative Neurology·D C McIntyreW A Staines
Sep 1, 1997·Cerebral Cortex·Y Kawaguchi, Y Kubota
Feb 7, 1998·The Journal of Comparative Neurology·D S MelchitzkyD A Lewis
Mar 10, 1998·The Journal of Comparative Neurology·R D Burwell, D G Amaral
Aug 13, 1998·The Journal of Comparative Neurology·R D Burwell, D G Amaral
Jul 28, 1999·The Journal of Comparative Neurology·B Faulkner, T H Brown
Jan 29, 2000·Nature Neuroscience·K ChoZ I Bashir
Jul 27, 2000·Annals of the New York Academy of Sciences·M P WitterT Van Haeften
Mar 20, 2001·Nature Reviews. Neuroscience·M W Brown, J P Aggleton
Dec 4, 2001·Journal of Neurophysiology·M MartinaD Paré

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Citations

Mar 31, 2007·Experimental Brain Research·Yasuko Sugase-Miyamoto, Barry J Richmond
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michele FerranteGiorgio A Ascoli
Aug 16, 2011·Cerebral Cortex·Gunes UnalDenis Paré
Jul 10, 2008·Learning & Memory·Rony PazDenis Paré
Mar 1, 2012·Neuroscience and Biobehavioral Reviews·Brendan E Depue
Oct 31, 2006·Trends in Neurosciences·Menno P Witter, Edvard I Moser
Oct 11, 2007·The Journal of Comparative Neurology·Ryohei Tomioka, Kathleen S Rockland
Jun 28, 2006·The European Journal of Neuroscience·John Apergis-SchouteDenis Paré
Sep 5, 2007·The European Journal of Neuroscience·Toshio Miyashita, Kathleen S Rockland
Feb 12, 2013·Current Opinion in Neurobiology·Rony Paz, Denis Pare
Feb 12, 2013·Current Opinion in Neurobiology·Antonio CaputiHannah Monyer
Nov 17, 2017·Brain Structure & Function·Maximilian SchmidtSacha J van Albada
Jul 6, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Saurabh SaigalDinesh Kumar Singh
Feb 16, 2016·Journal of Neuroscience Research·Alexander J McDonald, David D Mott
Nov 16, 2017·Journal of Computational Neuroscience·Yazan N Billeh, Michael T Schaub
Aug 5, 2020·Nature Reviews. Neuroscience·Sarah Melzer, Hannah Monyer
Jul 14, 2017·Frontiers in Systems Neuroscience·Menno P WitterShinya Ohara
Aug 10, 2021·Frontiers in Cellular Neuroscience·Noemi BininiGerardo Rosario Biella

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