PMID: 184884Jan 1, 1976

Feeding and body temperature in the rat: diencephalic localization of changes produced by excess calcium ions

Brain Research Bulletin
R D MyersC V Gisolfi

Abstract

In the unanesthetized rat, Ca++ ions in solutions ranging from 2.6 to 112.0 mM in excess of the normal level in CSF were applied at different sites in the brain and by three separate procedures, Colonic temperature was monitored and in certain experiments, the amount of food pellets and water consumed was measured simultaneously following the administration of excess Ca++ ions. An infusion into the lateral cerebral ventricle of excess calcium in a volume of 5.0 mul produced a concentration-dependent hypothermia, This fall in temperature was not attenuated by a prior intraventricular infusion of mecamylamine and often enhanced by atropine. Depending on the site, a microinjection of excess Ca++ ions in a volume of 0.5 to 1.0 mul directly into the hypothalamus produced hypothermia or feeding. The sites of maximum sensitivity at which excess calcium caused a decline in temperature were clustered in the caudal hypothalamus, whereas those at which calcium elicited feeding were distributed widely in caudo-lateral, medial and rostral hypothalamic areas. Push-pull perfusions at a rate of 20 to 25 mul per min for 10 to 20 min at homologous sites caused similar responses but the cation concentration required to evoke feeding or hypothermi...Continue Reading

References

Jan 1, 1974·Pflügers Archiv : European journal of physiology·B Sadowski, E Szczepańska-Sadowska
May 1, 1973·Physiology & Behavior·J R Seoane, C A Baile
Aug 17, 1973·Science·J L Hanegan, B A Williams
Dec 1, 1959·The Journal of Comparative Neurology· de GROOT

Citations

Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·R de Beaurepaire, W J Freed
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R D Myers, D H Ross
Jan 1, 1977·Brain Research Bulletin·W L VealeT Malkinson
Mar 1, 1978·Brain Research Bulletin·N C WilsonM I Phillips
Apr 1, 1980·Pharmacology, Biochemistry, and Behavior·M J PerlowR J Wyatt
Oct 3, 2001·Physiological Reviews·M G Tordoff

Related Concepts

Metazoa
Functional Cerebral Localization
Calcium
Structure of Diencephalon
Feeding Patterns
Hypothermia, Accidental
Synaptic Transmission
Cholinergic Receptors
Receptors, Drug
Rats, Laboratory

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