Feeding cancer's sweet tooth: specialized tumour vasculature shuttles glucose in pancreatic ductal adenocarcinoma

The Journal of Pathology
Andrew C Dudley, Victoria L Bautch

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal neoplasm characterized by a 'fortress' of thick collagen fibres, abundant myofibroblasts, and paradoxically reduced vascularization compared to normal pancreas. Despite these features, PDAC shows no reduction in the uptake of glucose that fuels tumour cell survival. In new work published in The Journal of Pathology, Saiyin and colleagues have identified a novel adaptation of PDAC tumour endothelium; namely, 'hairy-like' basal microvilli that increase the total vascular surface area and correlate with regions of highest glucose uptake. Since basal microvilli are not present on normal pancreatic blood vessels, their presence may add diagnostic value and blocking their function is a potential new treatment strategy for PDAC. This novel finding of basal microvilli on PDAC endothelium is a striking example of how phenotypic plasticity in tumour blood vessels contributes to tumour growth and progression, independent of conventional modes of angiogenesis.

References

Aug 30, 2008·Cell and Tissue Research·William C Aird
Jun 13, 2009·Science·Peter Olson, Douglas Hanahan
Apr 30, 2010·The New England Journal of Medicine·Manuel Hidalgo
Jul 16, 2010·Developmental Cell·Mikala EgebladZena Werb
Mar 12, 2011·Circulation Research·Anastasia D EgorovaBeerend P Hierck
Dec 16, 2011·Differentiation; Research in Biological Diversity·Anastasia D EgorovaBeerend P Hierck
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Andrew C Dudley

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