Feeding dried chicory root to pigs decrease androstenone accumulation in fat by increasing hepatic 3β hydroxysteroid dehydrogenase expression

The Journal of Steroid Biochemistry and Molecular Biology
Martin Krøyer RasmussenBo Ekstrand

Abstract

The present study investigated the in vivo effect of chicory root on testicular steroid concentrations and androstenone metabolizing enzymes in entire male pigs. Furthermore, the effect on skatole and indole concentrations in plasma and adipose tissue was investigated. The pigs were divided into two groups; one receiving experimental feed containing 10% dried chicory root for 16 days before slaughter, the control group was fed a standard diet. Plasma, adipose and liver tissue samples were collected at slaughter. Plasma was analyzed for the concentration of testosterone, estradiol, insulin-like growth factor 1 (IGF-1), skatole and indole. Adipose tissue was analyzed for the concentration of androstenone, skatole and indole, while the liver tissue was analyzed for mRNA and protein expressions of 3β-hydroxysteroid dehydrogenase (3β-HSD), sulfotransferase 2A1 and heat-shock protein 70 (HSP70). The results showed that the androstenone concentrations in the adipose tissue of chicory fed pigs were significantly (p<0.05) lower and indole concentrations were higher (p<0.05) compared to control fed pigs. Moreover the chicory root fed pigs had increased mRNA and protein expression of 3β-HSD and decreased HSP70 expression (p<0.05). Testost...Continue Reading

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Citations

Sep 5, 2013·International Journal of Molecular Sciences·Martin Krøyer RasmussenGalia Zamaratskaia
Aug 29, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Martin Krøyer RasmussenBo Ekstrand
Jan 1, 2012·Animals : an Open Access Journal From MDPI·Raffael Wesoly, Ulrike Weiler
May 1, 2012·Molecular Biology Reports·Martin Krøyer RasmussenGalia Zamaratskaia
Mar 17, 2020·Archives of Toxicology·Martin Krøyer Rasmussen
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Dana Carina SchubertChristian Visscher

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