PMID: 8613903Apr 1, 1996Paper

Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice

The Journal of Nutrition
M FriedmanB E Mackey

Abstract

Reduced liver weight was used to evaluate the potential toxicity in mice of four naturally occurring steroidal glycoalkaloids: alpha-chaconine and alpha-solanine, alpha-tomatine and solasonine. Increased liver weights was used to evaluate the three corresponding steroidal aglycones: solanidine, tomatidine, and solasodine and the non-alkaloid adrenal steroid dehydroepiandrosterone (DHEA). Adult female Swiss-Webster mice were fed diets containing test compound concentrations of 0 (control), 1.2, 2.4 or 4.8 mmol/kg diet for 7, 14 or 28 d. Absolute liver weights (LW) and relative liver weights (liver weight/body weight x 100, %LW/BW) were determined at autopsy. The %LW/BW was lower than that of controls in mice fed the potato glycoalkaloid alpha-chaconine (-10%, P < or = 0.05) for 7 d with the 2.4 mmol/kg diet dose. Under these same conditions, %LW/BW was greater than that of controls in mice fed two aglycones: solanidine (27%, P < or = 0.001) and solasodine (8%, P < or = 0.01). Relative liver weight increases induced by the aglycones were determined under time and dose conditions in which differences in body weight and food consumption were not significant (2.4 mmol/kg diet for 28 d). Under these conditions, the observed %LW/BW in...Continue Reading

Citations

Apr 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A C P OliveiraM M Coelho
Sep 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P R GuimarãesJ I Alvarez-Leite
Apr 23, 2010·Biological & Pharmaceutical Bulletin·Ming-Kun LuPin-Shern Chen
Aug 9, 2011·Molecular Nutrition & Food Research·Irina I KolevaIvonne M C M Rietjens
Apr 22, 2010·Journal of Medicinal Food·István KissIstván Ember
Oct 12, 2010·Biological & Pharmaceutical Bulletin·Ming-Kun LuPin-Shern Chen
Aug 15, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun-Hung ShenPin-Shern Chen
Aug 14, 2020·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Bettina Grasl-Kraupp
Dec 4, 2008·Fundamental & Clinical Pharmacology·Ashraf BahgatMohamed T Khayyal
May 18, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavel TomsikMartina Rezacova
Jan 28, 2015·Molecular Medicine Reports·Huarong HuangXi Zheng
Aug 15, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M FriedmanW E Yokoyama
Oct 20, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M L McWilliamsM Friedman
Jul 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J T BlankemeyerM Friedman
Apr 20, 2010·Journal of Agricultural and Food Chemistry·María-Cortes Sánchez-MataJaime Prohens
Jun 10, 2010·Journal of Agricultural and Food Chemistry·Giuseppe MennellaRoberto Lo Scalzo
Mar 16, 2011·Journal of Agricultural and Food Chemistry·Sinead Eileen MilnerAnita Rose Maguire
Jun 15, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tafadzwa MandimikaAd Peijnenburg
Nov 9, 2006·Journal of Agricultural and Food Chemistry·Mendel Friedman
Oct 3, 2002·Journal of Agricultural and Food Chemistry·Mendel Friedman
Nov 2, 2007·Journal of Agricultural and Food Chemistry·Tafadzwa MandimikaAd Peijnenburg
May 13, 2004·Journal of Agricultural and Food Chemistry·Kap-Rang LeeMendel Friedman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M FriedmanB E Mackey
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
L Crawford, B Myhr
© 2021 Meta ULC. All rights reserved