Feeding orange pulp improved bone quality in a rat model of male osteoporosis

Journal of Medicinal Food
Rori MorrowBarbara J Stoecker

Abstract

Oxidative stress and inflammation have been linked to bone loss. We evaluated the effects of feeding orange pulp (OP), a source of vitamin C and flavonoids, on bone quality in a rat model of male osteoporosis. One-year-old retired breeder rats (n = 43) were orchidectomized (ORX) or sham-operated (SHAM). Three days postsurgery, ORX rats were randomly assigned to treatments: ORX or ORX with 2.5% OP, 5% OP, or 10% OP. Diets were isonitrogenous, isocaloric, modified AIN-93M diets with equal fiber content. All ORX rats were fed for 4 months to the mean food intake of the SHAM group. At the end of the study blood, urine and bone samples were collected. Plasma antioxidant capacity and urinary deoxypyridinoline (DPD) were determined. Bone density, structure, and strength were assessed using dual energy X-ray absorptiometry, microcomputed tomography, and finite element analyses. ORX decreased (P < .05) antioxidant status, while OP as low as 2.5% maintained the antioxidant capacity of ORX rats comparable to that of the SHAM group. Cortical thickness at the tibial midshaft was significantly decreased by ORX and increased by OP, and urinary DPD was significantly increased by ORX and decreased by OP. In fourth lumbar trabecular cores, ORX r...Continue Reading

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Citations

Aug 15, 2012·Journal of Nutrition in Gerontology and Geriatrics·Connie M WeaverMartin J Ronis
Sep 13, 2015·Biochemical and Biophysical Research Communications·Ting WangChaoyin Jiang
Dec 19, 2012·Nutrition Research·Chwan-Li ShenIn-Sook Kwun
Aug 15, 2012·Journal of Nutrition in Gerontology and Geriatrics·Ock K ChunWon O Song
Feb 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Manuel J Favela-HernándezMaría del Rayo Camacho-Corona
Jul 9, 2011·Journal of Orthopaedic Trauma·Edward J HarveyRobert Geoffrey Richards
Jan 14, 2021·Critical Reviews in Food Science and Nutrition·Yue WangChong-De Sun
Apr 14, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Manuel J Favela-HernándezMaría del Rayo Camacho-Corona

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