PMID: 9449144Feb 4, 1998Paper

Feeding response to mercaptoacetate in Osborne-Mendel and S5B/PL rats

Obesity Research
L K SingerG A Bray

Abstract

The purpose of this experiment was to determine if Osborne-Mendel (OM) rats, which are susceptible to dietary-induced obesity, and S5B/PL (S5B) rats, which are resistant to dietary-induced obesity, differ in their feeding responses to mercaptoacetate (MA), which blocks fatty acid oxidation, or 2-deoxy-D-glucose (2DG), which blocks glucose utilization. 2DG (100 mg/kg or 200 mg/kg) increased food intake in both strains of rats on a high-fat diet (56% energy from fat). Mercaptoacetate (600 mumol/kg) increased food intake in OM but not S5B rats on a high-fat diet. When maintained on a low-fat diet (10% energy from fat), MA (400 mumol/kg or 600 mumol/kg) stimulated food intake in OM rats, whereas S5B rats increased food intake only after the highest dose of MA (600 mumol/kg). MA stimulated carbohydrate and protein intake in OM rats maintained on a macronutrient selection diet, whereas S5B rats maintained on this diet did not significantly increase intake of any macronutrient after MA. These results demonstrate that OM and S5B rats have a similar food intake response to 2DG but a dissimilar response to MA. The variable response to MA in these strains may be due to a difference in peripheral or central signaling systems related to fat...Continue Reading

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Citations

Jan 8, 2000·Physiology & Behavior·L K SingerG A Bray
Sep 21, 2000·The Proceedings of the Nutrition Society·G A Bray
Nov 14, 2002·Obesity Research·Andrea O SchaffhauserDavid A York
Jul 25, 2000·Journal of Dairy Science·K L Ingvartsen, J B Andersen
Dec 22, 1999·Endocrine Reviews·G A Bray, F L Greenway
Jul 1, 1997·Obesity Research·C Erlanson-Albertsson, D York
Dec 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wolfgang LanghansMyrtha Arnold
Jul 18, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·R W TylG D Jahnke

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