Feeding-State-Dependent Modulation of Temperature Preference Requires Insulin Signaling in Drosophila Warm-Sensing Neurons

Current Biology : CB
Yujiro UmezakiFumika N Hamada

Abstract

Starvation is life-threatening and therefore strongly modulates many aspects of animal behavior and physiology [1]. In mammals, hunger causes a reduction in body temperature and metabolism [2], resulting in conservation of energy for survival. However, the molecular basis of the modulation of thermoregulation by starvation remains largely unclear. Whereas mammals control their body temperature internally, small ectotherms, such as Drosophila, set their body temperature by selecting an ideal environmental temperature through temperature preference behaviors [3, 4]. Here, we demonstrate in Drosophila that starvation results in a lower preferred temperature, which parallels the reduction in body temperature in mammals. The insulin/insulin-like growth factor (IGF) signaling (IIS) pathway is involved in starvation-induced behaviors and physiology and is well conserved in vertebrates and invertebrates [5-7]. We show that insulin-like peptide 6 (Ilp6) in the fat body (fly liver and adipose tissues) is responsible for the starvation-induced reduction in preferred temperature (Tp). Temperature preference behavior is controlled by the anterior cells (ACs), which respond to warm temperatures via transient receptor potential A1 (TrpA1) [4]...Continue Reading

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Citations

Sep 27, 2018·G3 : Genes - Genomes - Genetics·Maria E YurgelAlex C Keene
Oct 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Lin Ling, Alexander S Raikhel
Jun 12, 2021·Integrative and Comparative Biology·Jessleen K KanwalSara Wasserman
Aug 14, 2021·Frontiers in Physiology·Elodie PrinceMarko Brankatschk

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