FEES-based assessment of pharyngeal hypesthesia-Proposal and validation of a new test procedure

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Bendix LabeitRainer Dziewas

Abstract

Intact pharyngeal sensation is essential for a physiological swallowing process, and conversely, pharyngeal hypesthesia can cause dysphagia. This study introduces and validates a diagnostic test to quantify pharyngeal hypesthesia. A total of 20 healthy volunteers were included in a prospective study. Flexible endoscopic evaluation of swallowing (FEES) and a sensory test were performed both before and after pharyngeal local anesthesia. To test pharyngeal sensation, a small tube was positioned transnasally in the upper third of the oropharynx with contact to the lateral pharyngeal wall. Increasing volumes of blue-dyed water were injected through the tube, and the latency of swallowing response (LSR) was determined by two independent raters from the endoscopic video recording. Three trials were performed for each administered volume starting with 0.1 mL and increased by 0.1 mL up to 0.5 mL. The average LSR without anesthesia was 2.24 ± 0.80 s at 0.1 mL, 1.79 ± 0.84 s at 0.2 mL, 1.29 ± 0.62 s at 0.3 mL, 1.17 ± 0.41 s at 0.4 mL, and 1.19 ± 0.52 s at 0.5 mL. With anesthesia applied, the average LSR was 2.65 ± 0.62 s at 0.1 mL, 2.64 ± 0.49 s at 0.2 mL, 2.44 ± 0.65 s at 0.3 mL, 2.10 ± 0.80 s at 0.4 mL, and 2.18 ± 0.85 s at 0.5 mL. LSR ...Continue Reading

References

Oct 1, 1993·The Annals of Otology, Rhinology, and Laryngology·J E AvivA Blitzer
Jan 9, 1998·The American Journal of Medicine·J E Aviv
May 22, 1998·The Annals of Otology, Rhinology, and Laryngology·J E AvivL G Close
Dec 9, 1998·The Anatomical Record·I Sanders, L Mu
Jul 17, 1999·The American Journal of Physiology·S HamdyN E Diamant
Mar 29, 2000·The Anatomical Record·L Mu, I Sanders
Feb 13, 2001·Journal of Neurophysiology·R E MartinR S Menon
Jun 8, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M SetzenM K Ditkoff
May 7, 2002·The Annals of Otology, Rhinology, and Laryngology·Lucian SulicaAndrew Blitzer
Feb 20, 2004·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Karen B ZurIra Sanders
Sep 13, 2007·The Annals of Otology, Rhinology, and Laryngology·Jeffrey J CunninghamGregory N Postma
Nov 6, 2007·Human Brain Mapping·Inga K TeismannChristo Pantev
Feb 19, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·T WarneckeR Dziewas
Jul 9, 2008·Acta Oto-laryngologica·Richard L DotyLiancai Mu
Sep 29, 2009·Chest·Kunihiko TeradaMichiaki Mishima
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Tobias WarneckeRainer Dziewas
Sep 4, 2010·Dysphagia·Catriona M Steele, Arthur J Miller
Jun 19, 2013·Journal of Neuropathology and Experimental Neurology·Liancai MuUNKNOWN Arizona Parkinson’s Disease Consortium
Jan 21, 2014·Dysphagia·Suely Mayumi Motonaga OnofriRoberto Oliveira Dantas
Sep 17, 2014·The Annals of Otology, Rhinology, and Laryngology·Asako KaneokaSusan E Langmore
Sep 26, 2014·Current Otorhinolaryngology Reports·Amanda S DomerPeter C Belafsky
Dec 3, 2015·Nature Reviews. Gastroenterology & Hepatology·Nathalie Rommel, Shaheen Hamdy
Jun 23, 2016·Journal of Chiropractic Medicine·Terry K Koo, Mae Y Li
Oct 28, 2016·Annals of the New York Academy of Sciences·Daniel Alvarez-BerdugoPere Clavé
Apr 17, 2017·Journal of the American Medical Directors Association·Omar OrtegaPere Clavé
Jul 22, 2017·American Journal of Speech-language Pathology·Asako KaneokaSusan E Langmore
Apr 26, 2019·Neurological Research and Practice·Rainer DziewasTobias Warnecke

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Citations

Oct 22, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Bendix LabeitTobias Warnecke
May 18, 2020·Parkinsonism & Related Disorders·Bendix LabeitTobias Warnecke

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