Felbamate in therapy-resistant epilepsy: an Italian experience. Felbamate Italian Study Group

Epilepsy Research
G AvanziniF Vigevano

Abstract

We evaluated the use of felbamate in 379 adults and children with refractory epilepsies in an open-label, compassionate clinical use setting. Prior to the termination of the program, because of reports of aplastic anemia, 351 patients had completed 2 months of treatment with felbamate at a dose of 2400-3600 mg/day for adults or 30-45 mg/kg/day for children. Of the 246 patients who had a diagnosis of therapy-refractory localization-related epilepsy with or without secondary generalization, 52% (126/246) achieved a seizure reduction of 50% or more, including 10% (25/246) who became seizure free. There was no difference in response rate between adults and children. Of the 80 patients who had a diagnosis of Lennox-Gastaut syndrome (LGS), 60% (48/80) achieved a seizure reduction of 50% or more, including 6% (5/80) who became seizure free. Of the 25 patients with a diagnosis of generalized epilepsy (other than LGS) or undetermined epilepsy whether focal or generalized, 60% (15/25) achieved a seizure reduction of 50% or more, including 12% (3/24) who became seizure free. The results of this uncontrolled study suggest that felbamate could be useful in patients with epilepsies which are refractory to other antiepileptic drugs after care...Continue Reading

References

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Citations

Apr 8, 1999·Epilepsy Research·R CangerL Guidolin
Jul 19, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S GrossoP Balestri
Apr 2, 2009·Neuropsychiatric Disease and Treatment·Kenou van Rijckevorsel
Feb 12, 2004·CNS Drugs·Giangennaro Coppola
Mar 3, 2010·CNS Drugs·Dean P Sarco, Blaise F D Bourgeois
Apr 29, 1998·Current Opinion in Neurology·J W Sander
Jul 6, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D Schmidt, B Bourgeois

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