Feline acromegaly: an essential differential diagnosis for the difficult diabetic

Journal of Feline Medicine and Surgery
S J M Niessen

Abstract

Clinicians who deal with diabetic cats can have mixed experiences. Some patients are 'textbook cases', responding very well to insulin administration; others prove to be more challenging. Recent studies have shown a significant proportion of problem diabetic cats to have underlying acromegaly (hypersomatotropism). Recognising this syndrome in these cats will be key to successfully managing the concurrent diabetes. Just like the 'normal' (non-acromegalic) diabetic cat, the acromegalic diabetic cat tends to be a middle-aged to older male neutered domestic short hair. However, with increasing case experience, this signalment may change. Most patients are insulin resistant, although this may not be the initial presenting sign. No breed predispositions have been recognised to date. There is no single diagnostic test for feline acromegaly - a confident diagnosis relies on a combination of clinical signs, feline growth hormone and insulin-like growth factor 1 levels, and intracranial imaging. Additionally, the ideal treatment protocol has yet to be established. Currently, radiotherapy is considered by many to be the best treatment; however, costs, the need for multiple anaesthetics, and the often delayed and unpredictable treatment re...Continue Reading

References

Jul 1, 1990·Journal of Veterinary Internal Medicine·M E PetersonC D Lothrop
Dec 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A L BarkanI Z Beitins
May 1, 1995·The Journal of Clinical Investigation·J A MolG R Rutteman
Aug 26, 2000·Advances in Experimental Medicine and Biology·J A MolA Rijnberk
Mar 29, 2001·Annals of Clinical Biochemistry·J Butler
Nov 22, 2001·Journal of Feline Medicine and Surgery·E J Norman, C T Mooney
Jul 26, 2002·The Journal of Small Animal Practice·B Kaser-HotzC Reusch
Sep 13, 2002·Australian Veterinary Journal·L A AbrahamS A Holloway
May 12, 2004·Journal of Feline Medicine and Surgery·S R StarkeyD B Church
Jan 4, 2005·The Veterinary Clinics of North America. Small Animal Practice·Danièlle Gunn-Moore
Aug 23, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Fernando P DominiciDaniel Turyn
Sep 6, 2005·Journal of the American Animal Hospital Association·Charles A Hurty, Bente Flatland
Feb 20, 2007·Endocrine Pathology·Fateme SalehiSylvia L Asa
Jun 10, 2008·Expert Opinion on Emerging Drugs·Philippe Chanson
Jul 22, 2008·Journal of Feline Medicine and Surgery·Yaiza ForcadaLaura Blackwood
Sep 20, 2008·Domestic Animal Endocrinology·L I SlingerlandH S Kooistra
Feb 19, 2009·Cancer Research·Ivana De MartinoAlfredo Fusco
Dec 1, 2006·Veterinary and Comparative Oncology·M J BrearleyS J M Niessen

❮ Previous
Next ❯

Citations

Aug 6, 2013·New Zealand Veterinary Journal·C A O'LearyJ S Rand
Sep 11, 2012·Topics in Companion Animal Medicine·Deborah S Greco
May 7, 2015·Journal of Veterinary Internal Medicine·C J ScudderS J M Niessen
Jan 15, 2015·The Journal of Small Animal Practice·L J Davison
May 30, 2015·PloS One·Stijn J M NiessenDavid B Church
Jun 5, 2012·Journal of Feline Medicine and Surgery·Jo R SmithKate E Creevy
Jul 13, 2013·Journal of Feline Medicine and Surgery·Christopher R LambStijn J Niessen
Nov 8, 2014·Journal of Feline Medicine and Surgery·Bianca N LourençoKatharine F Lunn
Jan 5, 2012·The Journal of Veterinary Medical Science·Atsuko MuraiMasashi Yuki
Jun 19, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Anthony J FischettiMark E Peterson
May 12, 2017·JFMS Open Reports·Federico FracassiHans S Kooistra
Feb 24, 2021·Journal of Veterinary Internal Medicine·Kirsten L van BokhorstBjörn P Meij
Jan 16, 2021·Journal of the American Animal Hospital Association·Rachel RivenburgAnnie V Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved