PMID: 8970993Dec 1, 1996Paper

Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I

Journal of Virology
D B TresnanK V Holmes

Abstract

Two members of coronavirus serogroup I, human respiratory coronavirus HCV-229E and porcine transmissible gastroenteritis virus (TGEV), use aminopeptidase N (APN) as their cellular receptors. These viruses show marked species specificity in receptor utilization, as HCV-229E can utilize human but not porcine APN, while TGEV can utilize porcine but not human APN. To determine whether feline APN could serve as a receptor for two feline coronaviruses in serogroup I, feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FeCV), we cloned the cDNA encoding feline APN (fAPN) by PCR from cDNA isolated from a feline cell line and stably expressed it in FIPV- and FeCV-resistant mouse and hamster cells. The predicted amino acid sequence of fAPN shows 78 and 77% identity with human and porcine APN, respectively. When inoculated with either of two biologically different strains of FIPV or with FeCV, fAPN-transfected mouse and hamster cells became infected and viral antigens developed in the cytoplasm. Infectious FIPV was released from hamster cells stably transfected with fAPN. The fAPN-transfected mouse and hamster cells were challenged with other coronaviruses in serogroup I including canine coronavirus, porcine coronav...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Apr 1, 1989·The Journal of Clinical Investigation·A T LookS C Peiper
Jan 1, 1987·Advances in Experimental Medicine and Biology·N C Pedersen
Jan 1, 1987·Advances in Experimental Medicine and Biology·F W Scott
Jan 1, 1987·Advances in Experimental Medicine and Biology·J G KeckM M Lai
Mar 22, 1985·Science·S J O'BrienD E Wildt
Mar 1, 1986·Journal of Virology·S MakinoM M Lai
Jan 1, 1972·Veterinary Pathology·R J Montali, J D Strandberg
Jan 1, 1982·Physiological Reviews·A J Kenny, S Maroux
Mar 11, 1982·Nature·R G WebsterG C Schild
Apr 1, 1983·The Journal of General Virology·S SiddellV Ter Meulen
Mar 26, 1982·Science·J HollandS VandePol
May 1, 1993·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·X F YangG Boileau
Jan 1, 1993·Advances in Experimental Medicine and Biology·B DelmasH Laude
Jan 1, 1995·Advances in Experimental Medicine and Biology·R LevisK V Holmes

❮ Previous
Next ❯

Citations

Jul 11, 2007·Avian Pathology : Journal of the W.V.P.A·H Y ChenH C Chen
Dec 14, 2007·Journal of Virology·Gergely TekesHeinz-Jürgen Thiel
May 21, 2010·Journal of Virology·Andrew D ReganGary R Whittaker
Sep 10, 2010·Archives of Virology·Kazuya ShiratoFumihiro Taguchi
Mar 26, 2014·Journal of Animal Science·T GoetstouwersL J Peelman
Feb 6, 2015·Journal of Virology·Christine BurkardCornelis A M de Haan
Oct 31, 2015·Archives of Virology·Tomomi TakanoTsutomu Hohdatsu
Jan 25, 2007·Annual Review of Immunology·Jun Chen, Kanta Subbarao
Dec 23, 2004·Journal of Virology·Jolanda D F de Groot-MijnesRaoul J de Groot
Jun 10, 2008·Journal of Feline Medicine and Surgery·Niels C PedersenLeslie A Lyons
Apr 29, 2004·Journal of Virology·Brian C TurnerKathryn V Holmes
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott A JeffersKathryn V Holmes
Aug 17, 2006·FEMS Microbiology Reviews·Lia van der HoekBen Berkhout
Apr 1, 2006·Glycoconjugate Journal·Christel Schwegmann-Wessels, Georg Herrler
Feb 27, 2014·Veterinary Pathology·A Kipar, M L Meli
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Wentao LiBerend-Jan Bosch
Jan 22, 2004·Viral Immunology·Sonia Navas-Martin, Susan R Weiss
Sep 19, 2008·Journal of Virology·Andrew D Regan, Gary R Whittaker
Oct 29, 2005·Journal of Virology·Cornelis A M de HaanPeter J M Rottier
May 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Caroline LassnigMathias Müller
Jan 14, 2011·The Journal of General Virology·Juan RegueraJosé M Casasnovas
Dec 15, 2012·Virus Genes·Chao-Nan LinLing-Ling Chueh
Sep 23, 2014·Journal of Veterinary Science·Seok-Young JeoungDoo Kim
Feb 24, 2015·PloS One·Kaja ZuwałaKrzysztof Pyrc
Jan 16, 2020·Viruses·Javier A JaimesGary R Whittaker
May 15, 2020·Pathogens·Shasha LiHaixue Zheng
Oct 26, 2007·Journal of Virology·Olga SlobodskayaWilly J M Spaan
Jul 29, 2004·Journal of Virology·Ryuji NomuraToyoshi Fujimoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.