Feline calicivirus- and murine norovirus-induced COX-2/PGE2 signaling pathway has proviral effects

PloS One
Mia Madel AlfajaroKyoung-Oh Cho

Abstract

Cyclooxygenases (COXs)/prostaglandin E2 (PGE2) signaling pathways are known to modulate a variety of homeostatic processes and are involved in various pathophysiological conditions. COXs/PGE2 signaling pathways have also been demonstrated to have proviral or antiviral effects, which appeared different even in the same virus family. A porcine sapovirus Cowden strain, a member of genus Sapovirus within the Caliciviridae family, induces strong COX-2/PGE2 but transient COX-1/PGE2 signaling to enhance virus replication. However, whether infections of other viruses in the different genera activate COXs/PGE2 signaling, and thus affect the replication of viruses, remains unknown. In the present study, infections of cells with the feline calicivirus (FCV) F9 strain in the genus Vesivirus and murine norovirus (MNV) CW-1 strain in the genus Norovirus only activated the COX-2/PGE2 signaling in a time-dependent manner. Treatment with pharmacological inhibitors or transfection of small interfering RNAs (siRNAs) against COX-2 enzyme significantly reduced the production of PGE2 as well as FCV and MNV replications. The inhibitory effects of these pharmacological inhibitors against COX-2 enzyme on the replication of both viruses were restored by...Continue Reading

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Citations

Oct 22, 2019·Frontiers in Immunology·Yoatzin Peñaflor-TéllezAna Lorena Gutiérrez-Escolano
Mar 25, 2019·Viruses·Ulrich Desselberger

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Methods Mentioned

BETA
enzyme-linked immunoabsorbent assay
PCR
ELISA
transfection
confocal microscopy

Software Mentioned

LSM
Rotorgene 3000®

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