Feline giant-cell pleomorphic sarcoma: cytologic, histologic and immunohistochemical characterization.

Journal of Feline Medicine and Surgery
Bianca S de CeccoLuciana Sonne

Abstract

This study aimed to characterize the cytologic, pathologic and immunohistochemical (IHC) aspects of feline giant-cell sarcoma. Biopsy and necropsy reports from the Department of Veterinary Pathology were retrieved, and 13 cases of pleomorphic sarcoma (PS) were selected according to the established epidemiologic, pathologic and IHC criteria. All samples were fixed in 10% formalin, routinely processed for histology, and stained with hematoxylin and eosin. Samples also underwent IHC testing for vimentin, ionized calcium-binding adaptor molecule 1 (Iba-1), desmin, actin and S-100. The mean age of the affected cats was 9.5 years, and females were over-represented. Most neoplasms were observed in the flank, lateral thorax, limbs and interscapular region, and were >2 cm in diameter. Cytology analysis revealed highly cellular preparations with three distinct populations (spindle cells, small round cells and multinucleated giant cells) in a dense eosinophilic stroma. Histologically, PS was composed of a combination of these three populations. IHC labeling for vimentin and Iba-1 was strongly positive for spindle cells and multinucleated giant cells, respectively. Desmin/actin showed variable labeling among the samples. S-100 was negative...Continue Reading

References

Mar 1, 1979·Veterinary Pathology·C A GleiserK N Gray
Sep 1, 1987·Journal of Comparative Pathology·A Garma-Aviña
Nov 15, 1984·Cancer·Y S LeeA Nather
Jan 1, 1994·Veterinary Pathology·M J Hendrick, J J Brooks
Feb 1, 1996·Journal of Comparative Pathology·F D DoddyE B Janovitz
Jun 22, 1999·Head & Neck·S G PatelP H Evans
Jul 10, 2002·Veterinary Pathology·S S CoutoB R Madewell
Nov 1, 1964·Cancer·J E O'BRIEN, A P STOUT
Oct 1, 2003·Skeletal Radiology·A E Rosenberg
Jul 20, 2005·The British Journal of Oral & Maxillofacial Surgery·T SabesanV Ilankovan
Oct 3, 2007·The British Journal of Radiology·Y MakimotoK Hayasaki
Feb 21, 2008·Journal of Surgical Oncology·Alessandra F Nascimento, Chandrajit P Raut
Mar 4, 2008·Journal of Feline Medicine and Surgery·Meighan K DalyNicole C Northrup
Jan 22, 2010·Veterinary Clinical Pathology·Jamie L HaddadReema T Patel
Apr 14, 2011·Odontology·Takafumi SatomiHiroshige Chiba
May 26, 2012·Journal of Feline Medicine and Surgery·Marina MartanoPaolo Buracco
Jun 9, 2012·Journal of the American Academy of Dermatology·Michael T Henderson, S Tyler Hollmig
Jun 24, 2015·Journal of Feline Medicine and Surgery·Katrin HartmannUNKNOWN European Advisory Board on Cat Diseases
Jul 26, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Takashi KoteraJyoji Yamate
Sep 22, 2017·Journal of Thoracic Disease·Xiongfei LiSong Xu

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