Feline immunodeficiency virus xenoinfection: the role of chemokine receptors and envelope diversity

Journal of Virology
J B Johnston, C Power

Abstract

The use of chemokine receptors as cell recognition signals is a property common to several lentiviruses, including feline, human, and simian immunodeficiency viruses. Previously, two feline immunodeficiency virus (FIV) isolates, V1CSF and Petaluma, were shown to use chemokine receptors in a strain-dependent manner to infect human peripheral blood mononuclear cells (PBMC) (J. Johnston and C. Power, J. Virol. 73:2491-2498, 1999). Since the sequences of these viruses differed primarily in regions of the FIV envelope gene implicated in receptor use and cell tropism, envelope chimeras of V1CSF and Petaluma were constructed to investigate the role of envelope diversity in the profiles of chemokine receptors used by FIV to infect primate cells. By use of a receptor-blocking assay, all viruses were found to infect human and macaque PBMC through a mechanism involving the CXCR4 receptor. However, infection by viruses encoding the V3-to-V5 region of the V1CSF surface unit was also inhibited by blockade of the CCR3 or CCR5 receptor. Similar results were obtained with GHOST cells, human osteosarcoma cells expressing specific combinations of chemokine receptors. CXCR4 was required for infection by all FIV strains, but viruses expressing the ...Continue Reading

References

May 1, 1989·Veterinary Immunology and Immunopathology·N C PedersenH Hansen
May 1, 1995·Veterinary Immunology and Immunopathology·K H SiebelinkM L Bosch
Sep 1, 1993·Journal of Virology·R V EnglishM B Tompkins
Jan 1, 1994·Current Topics in Microbiology and Immunology·G PancinoP Sonigo
Dec 31, 1997·Science·K A MartinN P Gerard
Jan 10, 1998·The Journal of Biological Chemistry·M BenkiraneK T Jeang
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·T M Ross, B R Cullen
Apr 23, 1999·Journal of Reproductive Immunology·J A HoxieT J Matthews
May 20, 1999·Molecular Membrane Biology·B J Willett, M J Hosie
Nov 13, 1999·Journal of Virology·W HofmannJ Sodroski
Dec 10, 1999·Journal of Virology·C A WilsonM J Federspiel
Sep 14, 2000·Current Biology : CB·O T Fackler, B M Peterlin
Aug 18, 2001·Current Biology : CB·J B JohnstonC Power

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Citations

Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rick B Meeker
Apr 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fayth K YoshimuraAlan P Hudson
Apr 24, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria J PolyakChristopher Power
Jul 12, 2011·Veterinary Immunology and Immunopathology·Reinhard ErtlDieter Klein
Dec 3, 2013·Acta Microbiologica Et Immunologica Hungarica·Balázs SterczJózsef Ongrádi
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu ZhuChristopher Power

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