PMID: 6172390Aug 15, 1981Paper

Feline leukemia - unique and cross-relating antigens on individual virus-producing tumors identified by complement-dependent antibody

International Journal of Cancer. Journal International Du Cancer
C K Grant, M T Michalek

Abstract

Following exposure to feline leukemia virus (FeLV), cats that resist leukemia produce complement dependent antibodies (CDA) which lyse leukemia cells in the presence of cat complement. The CDA activity has been shown to be directed to feline oncornavirus-associated cell membrane antigen (FOCMA) found on the surface of most feline leukemias. Despite the retrovirus etiology of feline leukemia, and the ubiquity of FOCMA expression by individual tumors, we found that CDA activity did not cross-react when five feline leukemia lines were compared (FL74, F422, 3272, 3281, and 79-14940). Profiles for CDA mediated lysis of the leukemia target lines were determined for sera from 149 FeLV exposed cats, and animals were identified whose sera would selectively lyse almost any possible combination of tumors from one to five lines tested. Cross absorption and cold target inhibition studies were performed on selected sera, and a spectrum of different antigens was identified which included both individual determinants and antigens shared by some of the tumor lines. Leukemias FL74 and F422 carried a cross-reactive determinant which was distinct from a second antigen shared by 3272 and 3281; lines F422, 3272 and 3281 each also carried a unique an...Continue Reading

References

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Citations

May 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R W EngelmanN K Day
May 15, 1983·International Journal of Cancer. Journal International Du Cancer·J M McCarty, C K Grant
May 1, 1984·Veterinary Immunology and Immunopathology·J L Rojko, R G Olsen
Nov 13, 2008·Cytotechnology·Nozomu EtoYukuharu Kobayashi

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