Feline programmed death and its ligand: characterization and changes with feline immunodeficiency virus infection

Veterinary Immunology and Immunopathology
A FolklD Bienzle

Abstract

Programmed death (PD)-1 and its ligand, PD-L1, are co-stimulatory molecules expressed on T cells and antigen-presenting cells, respectively, that modulate T cell receptor signals. Altered PD expression or signalling contributes to pathogen persistence in chronic infections. The sequence of the feline PD genes was derived from gene amplification with primers conserved across human and canine homologs, and by sequence extension through rapid amplification of cDNA ends. Feline PD-1 was similar to that of other mammalian species and consisted of extracellular, transmembrane and cytoplasmic regions. Functional motif analysis of the translated amino acid sequence predicted immunoreceptor tyrosine-based inhibitory and switch motifs, and a SH3-binding region, in the cytoplasmic tail. PD-1 and PD-L1 were expressed in resting lymphocytes and dendritic cells, and up-regulated on mitogen-activated or irradiated lymphocytes of both CD4 and CD8-positive subsets. In vitro infection with the feline immunodeficiency virus (FIV) significantly decreased PD-1, but not PD-L1, gene expression in lymphocytes at 24h, and decreased expression of both genes at 168h. No significant changes in gene or protein expression from FIV infection were noted in de...Continue Reading

References

Apr 4, 2002·The Journal of Infectious Diseases·Mary B TompkinsWayne A Tompkins
Jun 26, 2003·Nucleic Acids Research·Pål PuntervollToby J Gibson
Jun 26, 2003·Nucleic Acids Research·Elisabeth GasteigerAmos Bairoch
Mar 27, 2004·Current HIV Research·Mary Jo Burkhard, Gregg A Dean
Jun 26, 2004·The Journal of General Virology·F Reggeti, D Bienzle
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Jun 28, 2005·Nucleic Acids Research·E QuevillonR Lopez
Aug 19, 2006·Nature Medicine·Lydie TrautmannRafick-Pierre Sekaly
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Oct 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tsvetelina Pentcheva-HoangJames P Allison
Sep 2, 2008·Immunological Reviews·Brian T Fife, Jeffrey A Bluestone
Sep 19, 2008·Veterinary Immunology and Immunopathology·Angela M MexasMary B Tompkins

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Citations

Mar 19, 2014·Veterinary Immunology and Immunopathology·Dorothee Bienzle
Jul 2, 2011·Veterinary Immunology and Immunopathology·Andrea AchleitnerDorothee Bienzle
Mar 27, 2016·Immunobiology·Vanessa Marim ChikuValéria Marçal Felix de Lima
Jan 26, 2017·Veterinary and Comparative Oncology·J CoyS Dow
Oct 12, 2016·The Journal of Veterinary Medical Science·Satoru KonnaiKazuhiko Ohashi

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