Abstract
Oral squamous cell carcinomas (OSCCs) are common feline cancers. Why OSCCs are so common in cats is unknown; however, 25% of human OSCCs are caused by papillomaviruses (PVs). Two feline oral PVs (FcaPV-1 and 4) are recognized. As PVs are highly host and location specific, if PVs do cause feline OSCCs, FcaPV-1 and 4 are the most likely etiological agents. PCR primers specific for FcaPV-1 amplified DNA from 1 of 36 feline OSCCs and 1 of 16 inflammatory oral lesions. No DNA was amplified by primers specific for FcaPV-4. PV DNA was not amplified from any additional sample using consensus primers. No PV cytopathology was visible in the OSCC that contained FcaPV-1 DNA, but viral cytopathology was present in a focus of epithelial hyperplasia in the non-neoplastic sample. This study does not support a PV etiology of feline OSCCs, but shows that FcaPV-1 can asymptomatically infect the mouth of cats.
References
Jan 22, 2000·Veterinary Pathology·J P SundbergA B Jenson
Jun 13, 2001·American Journal of Veterinary Research·B A KidneyM L Jackson
Jan 19, 2007·Head & Neck·Maura L Gillison
Jul 6, 2007·Veterinary Dermatology·John S MundayRichard A Squires
Aug 22, 2008·Research in Veterinary Science·J S MundayH Sugiarto
Jul 1, 2010·Veterinary Pathology·J S MundayK Gwynne
Jul 9, 2010·Veterinary Dermatology·Sarah H O'NeillStephen A Kania
Jul 14, 2010·Research in Veterinary Science·John S MundayAdrienne F French
Mar 12, 2011·Veterinary Dermatology·John S MundayAdrienne F French
Nov 19, 2013·Virus Genes·Magdalena DunowskaSimon F K Hills
Citations
Sep 13, 2016·Transboundary and Emerging Diseases·R M Gil da CostaD DiMaio
Mar 5, 2016·Veterinary Pathology·H J Klobukowska, J S Munday
Jan 6, 2018·Veterinary Sciences·Gennaro AltamuraGiuseppe Borzacchiello
Jun 8, 2018·The Journal of Veterinary Medical Science·Nanako Yamashita-KawanishiTakeshi Haga
Jan 24, 2020·Viruses·Maura CarraiJulia A Beatty
Jan 29, 2020·Veterinary and Comparative Oncology·Gennaro AltamuraGiuseppe Borzacchiello
Sep 22, 2018·Oncotarget·Hunter John PiegolsVilma Yuzbasiyan-Gurkan
Jun 30, 2015·Veterinary Sciences·Claire M Cannon
Nov 1, 2017·Transboundary and Emerging Diseases·G AltamuraG Borzacchiello
Aug 15, 2018·Veterinary Sciences·Walaa Hamed Shaker NasryChelsea K Martin
Dec 5, 2018·Scientific Reports·Gennaro AltamuraGiuseppe Borzacchiello
Nov 10, 2020·Frontiers in Microbiology·Gennaro AltamuraGiuseppe Borzacchiello
Aug 29, 2021·Viruses·John S Munday, Neroli A Thomson
Aug 31, 2021·Critical Reviews in Oncology/hematology·Roberto GrigolatoLuca Calabrese