Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-kappaB activation

Acta Pharmacologica Sinica
Hong-Wei TanWei Zhang

Abstract

Metabolic syndrome is associated with an increased incidence of atherosclerosis. Clinical studies have shown that calcium channel blockers (CCB) inhibit the progression of atherosclerosis. However, the underlying mechanism is unclear. We investigated the inhibitory effect of felodipine on adhesion molecular expression and macrophage infiltration in the aorta of high fructose-fed rats (FFR). Male Wistar rats were given 10% fructose in drinking water. After 32 weeks of high fructose feeding, they were treated with felodipine (5 mg x kg(-1) x d(-1)) for 6 weeks. The control rats were given a normal diet and water. The aortic expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and the infiltration of macrophages were measured by real-time RT-PCR and/or immunohistochemistry. NF-kappaB activity was measured by electrophoretic mobility shift assay (EMSA). After 32 weeks of high fructose feeding, FFR displayed increased body weight, systolic blood pressure (SBP), serum insulin, and triglycerides when compared with the control rats. The aortic expressions of ICAM-1 and VCAM-1 were significantly increased in FFR than in the control rats and accompanied by the increased activity of NF-ka...Continue Reading

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Citations

May 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nallasamy Palanisamy, Carani Venkataraman Anuradha
Jul 26, 2011·International Journal of Nephrology·Mohammed H AbdullaEdward J Johns
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Jun 25, 2015·Journal of Thrombosis and Thrombolysis·Plinio CirilloBruno Trimarco
Jan 26, 2021·In Silico Pharmacology·Mehmet Melih TatlisozCetin Canpolat

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