PMID: 7540527Mar 1, 1995Paper

Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash

Clinical Rheumatology
M F McMullin, M B Finch

Abstract

A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.

References

Jan 1, 1992·Scandinavian Journal of Rheumatology·H Nielsen, J Mejer
Jul 1, 1992·Baillière's Clinical Haematology·I Davis, G Morstyn
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Citations

Jul 28, 2005·Annals of Hematology·Michael Heuser, Arnold Ganser
Dec 30, 2016·Nature Reviews. Drug Discovery·John A HamiltonPaul P Tak
Jan 24, 2015·The Open Rheumatology Journal·Mohammad Bagher OwliaMojtaba Akhtari
Jun 1, 2019·International Cancer Conference Journal·Yasuyuki KinjoKiyoshi Yoshino

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