Female adnexal tumor of probable wolffian origin: a clinicopathological case report and a possible new treatment

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
H SteedD De Petrillo

Abstract

Female adnexal tumors of probable wolffian origin (FATWOs) are rare tumors arising in the broad ligament from the remnants of the mesonephric duct. We report a case of recurrent disease. A 15-year-old girl who presented with a painful pelvic mass underwent a laparotomy with tumor resection. Pathology findings confirmed a FATWO. The tumor recurred within 2 years and was treated with multiple chemotherapy regimens, including a platinum-based drug, and surgery for progressive disease. The tumor was positive for c-kit oncogene (CD 117). Gleevac therapy, a tyrosine kinase inhibitor, was prescribed, and she developed severe persistent lower abdominal pain 2 months later. She underwent a hysterectomy and debulking of retroperitoneal masses. Pathology showed evidence of tumor necrosis, suggesting a possible beneficial effect, and she was recommenced on Gleevac in an effort to prevent recurrences. She is currently asymptomatic, without evidence of disease 10 months after surgery, continuing on Gleevac therapy. FATWOs are very rare tumors. Most cases are benign but have the potential to recur and metastasize. There is limited knowledge about the optimal treatment for this neoplasm. Our patient's favorable response to Gleevac therapy supp...Continue Reading

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Citations

Oct 14, 2014·Indian Journal of Pathology & Microbiology·Arvind K GuptaRaje Nijhawan
Dec 1, 2009·Surgical Pathology Clinics·Julie A Irving
Jun 16, 2015·Gynecologic Oncology Reports·Ryota DeshimaruMineo Takahashi
Apr 30, 2016·The Journal of Obstetrics and Gynaecology Research·Mie SakaiIkuo Konishi
Jul 13, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Shuhui HongWenxin Zheng
Jul 6, 2018·The Journal of Obstetrics and Gynaecology Research·Lenan LiuYan Xing
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Suha DeenRobert H Hammond
Nov 6, 2008·Scandinavian Journal of Urology and Nephrology·Benjamin R GreyNoel W Clarke
Aug 31, 2019·Archives of Pathology & Laboratory Medicine·Akram Shalaby, Veena Shenoy
May 4, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Antonio CossuGiuseppe Palmieri
Nov 13, 2019·The American Journal of Surgical Pathology·Jennifer PorsLynn N Hoang
Oct 9, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer A BennettEsther Oliva
Aug 14, 2021·Gynecologic Oncology Reports·Maria de Pilar Estevez-DizJesus Paula Carvalho

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