Female age in ART: when to stop?

Gynecologic and Obstetric Investigation
F J Broekmans, E R Klinkert

Abstract

With increasing age the probability of ongoing pregnancy established by the use of assisted reproduction technology (ART) decreases. As a result the question arises whether age limits for the application of ART should be established. From a literature review and ongoing research data it appears that the costs per child born greatly increase after the age of 40 for both intrauterine insemination with mild ovarian stimulation and in vitro fertilisation treatment, while in cases of 44 and over, prognosis is flat zero. The willingness to pay for extra costs will greatly determine whether and at what age strict limits should be applied. Fortunately, predictive factors for success, like the antral follicle count, may enable the identification of women over 40 and under 44 that still have favourable prospects, thereby decreasing the necessary costs per childbirth and allowing couples into ART programs that are often denied based solely on female age.

References

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Citations

Oct 12, 2011·Human Reproduction Update·J F OudendijkS L Broer
Dec 25, 2007·BMC Health Services Research·Reija KlemettiElina Hemminki
Dec 25, 2009·Reproductive Biomedicine Online·J A CastillaB Coroleu
Nov 17, 2009·Reproductive Biomedicine Online·Ariel HourvitzJacob Levron
Mar 20, 2010·Reproductive Biomedicine Online·Göran PetterssonJoan-Carles Arce
Oct 4, 2005·Human Reproduction Update·L J A M JacobsH J M Smeets

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