Female hormones affect symptom severity in obsessive-compulsive disorder

International Clinical Psychopharmacology
Nienke C C VulinkHerman G M Westenberg

Abstract

There is circumstantial evidence that reproductive events can influence symptom severity of obsessive-compulsive disorder (OCD). We sent self-report questionnaires to 350 female outpatients with OCD to examine the relationship between the menstrual cycle, pregnancy, menopause, hormonal contraceptives, selective serotonin reuptake inhibitors and symptom severity of OCD. Yale-Brown Obsessive-Compulsive Scale scores were used at three serial time points during the menstrual cycle to assess symptom severity. One hundred and one out of 350 questionnaires (29%) were returned and completed. Forty-nine patients reported an exacerbation of OCD symptoms during the premenstrual period, nine during the menopause and 17 patients during pregnancy, whereas 11 patients mentioned improvement of OCD symptoms during pregnancy. Premenstrual dysphoric disorder could only partly explain a premenstrual exacerbation of OCD symptoms. Exacerbation of OCD could be related to reproductive events in a considerable number of patients, especially the premenstrum. Because reproductive cycle events influence the symptom severity of OCD, the menstrual cycle should be taken into account when assessing the severity of OCD symptoms during pharmacological studies.

References

Jul 1, 1991·European Journal of Radiology·F RasmussenJ Georgsen
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Feb 1, 1969·Archives of General Psychiatry·D W GoodwinE Robins
Nov 1, 1993·The American Journal of Psychiatry·L BaerA I Henriques
Aug 1, 1996·Behaviour Research and Therapy·G SteketeeK Bogart
Jul 1, 1997·The Journal of Clinical Psychiatry·K E Williams, L M Koran
Feb 20, 1999·Archives of General Psychiatry·G Skoog, I Skoog
Apr 7, 1999·The Journal of Clinical Psychiatry·K L WisnerB H Hanusa
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·J B Becker
Dec 12, 2001·Psychosomatics·J AbramowitzC Purdon
Jul 20, 2002·Journal of Affective Disorders·Kirsten A Oinonen, Dwight Mazmanian
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·J ZoharD Amital
Aug 6, 2003·The American Journal of Psychiatry·Lee S CohenJan L Shifren
Jan 8, 2004·American Journal of Obstetrics and Gynecology·Hadine JoffeBernard L Harlow
May 4, 2004·Biological Psychiatry·Damiaan DenysHerman G M Westenberg
Feb 12, 2005·The Journal of Clinical Psychiatry·Nienke C C VulinkHerman G M Westenberg
Apr 9, 2005·The Journal of Clinical Psychiatry·Javier LabadJulio Vallejo

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Citations

Jul 8, 2010·Archives of Women's Mental Health·Jonathan S AbramowitzCort Pedersen
Apr 18, 2009·Harvard Review of Psychiatry·Joanne CunninghamElias Eriksson
Sep 8, 2010·Social Cognitive and Affective Neuroscience·Lindsey OssewaardeErno J Hermans
Jun 4, 2010·Current Opinion in Psychiatry·Fisun Akdeniz
Jul 31, 2012·PloS One·Katriina TiiraHannes Lohi
Nov 30, 2011·Journal of Psychiatry & Neuroscience : JPN·Catherine LordGeoffrey B Hall
Dec 18, 2012·Women's Health·Elise Hall, Meir Steiner
Apr 17, 2012·Hormones and Behavior·Marina F PonzioMarta Fiol de Cuneo
Jul 10, 2007·Journal de gynécologie, obstétrique et biologie de la reproduction·J Dayan
Sep 13, 2011·Gender Medicine·Astrid BellemGillian Einstein
May 21, 2011·General Hospital Psychiatry·Faruk UguzErdinc Cicek
Nov 11, 2008·Hormones and Behavior·Shlomit Flaisher-GrinbergDaphna Joel
Apr 11, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Faruk UguzCemal Akman
Mar 21, 2007·European Journal of Pharmacology·Gaikwad UdayUmathe Sudhir
Jun 13, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Hilga KaterbergJohan A den Boer
May 15, 2015·European Archives of Psychiatry and Clinical Neuroscience·Riccardo Maria MartoniJoseph O'Neill
Aug 21, 2007·Comprehensive Psychiatry·Faruk UguzOmer Gecici
Feb 12, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sandra Olvera-HernándezAlonso Fernández-Guasti
Aug 10, 2011·Journal of Anxiety Disorders·Catherine LordMeir Steiner
Sep 26, 2013·Best Practice & Research. Clinical Obstetrics & Gynaecology·Samantha Meltzer-Brody, Alison Stuebe
Apr 27, 2012·General Hospital Psychiatry·Faruk UguzRustem Askin
Jan 20, 2015·Neuroscience and Biobehavioral Reviews·Michael T Ullman, Mariel Y Pullman
Dec 23, 2015·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Faruk Uguz
Feb 2, 2010·The Australian and New Zealand Journal of Psychiatry·Faruk UguzRengin Karatayli
Jun 26, 2008·The International Journal of Social Psychiatry·Tali VishneMichael E Bunzel
Dec 9, 2009·International Journal of Psychiatry in Medicine·J Frederieke van VeenFrans G Zitman
Sep 24, 2016·American Journal of Therapeutics·Faruk Uguz
Aug 11, 2011·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Kátia PetribúYgor Ferrão
Aug 23, 2019·Journal of Reproductive and Infant Psychology·Michelle L Miller, Michael W O'Hara
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman
Jan 1, 2008·International Journal of Psychiatry in Clinical Practice·Kazim GezginçOmer Geçici
Jun 7, 2019·Current Psychiatry Reports·Thalia RobakisNatalie L Rasgon
Jan 29, 2021·European Journal of Pharmacology·Anna Franceschini, Liana Fattore
Oct 29, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Semra AydoganKazim Gezginc
Dec 12, 2017·Neuropharmacology·Adriano Edgar ReimerMarcus Lira Brandão
May 11, 2021·Journal of Obsessive-compulsive and Related Disorders·Calliope HolinguePaul S Nestadt

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