Female infertility: which role for obesity?

International Journal of Obesity Supplements
Alessandra GambineriObesity Programs of nutrition, Education, Research and Assessment (OPERA) group

Abstract

Obesity is associated with infertility in women through multiple and complex mechanisms. Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty acids (FFA), and cytokines may affect both ovarian and endometrium functions, with a final alteration in oocyte maturation and endometrial epithelium receptivity. In addition, through the development of peripheral insulin resistance obesity produces a condition of functional hyperandrogenism and hyperestrogenism that contribute to produce anovulation and to reduce endometrial receptivity and, therefore participate to cause infertility. Weight loss is able to restore fertility in most cases, but there are no practical indications to guide the clinician to choice the best method among increased physical activity, diet, drugs, and bariatric surgery.

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Citations

Apr 25, 2020·International Journal of Environmental Research and Public Health·Pia JägerMetin Senkal
Aug 28, 2020·Frontiers in Endocrinology·Antonio AversaAlberto Ferlin
Dec 22, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Chiara Di TucciPierluigi Benedetti Panici
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zdravko Kamenov, Antoaneta Gateva
Feb 6, 2021·Curēus·Iana MalasevskaiaStacey E Heindl
Apr 12, 2021·Nursing for Women's Health·Megan W ArbourJudith C Wika
May 1, 2021·International Journal of Molecular Sciences·Karolina WołodkoAntónio Galvão
May 16, 2021·British Journal of Clinical Pharmacology·Jurjen S KingmaCatherijne A J Knibbe
Jun 17, 2021·European Journal of Clinical Nutrition·Bettina Hieronimus, Regina Ensenauer
Nov 4, 2021·Reproductive Sciences·Rasha A Al-LamiSana M Salih
Dec 9, 2021·Wiener klinische Wochenschrift·Dragan D MicicSnezana P Polovina

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