Female rats are more susceptible to metabolic effects of dehydroepiandrosterone treatment

Canadian Journal of Physiology and Pharmacology
Ana Lúcia HoefelLuiz Carlos Rios Kucharski

Abstract

Dehydroepiandrosterone (DHEA) is a steroid hormone that presents several effects on metabolism; however, most of the studies have been performed on male animals, while few authors have investigated possible sex differences regarding the metabolic effects of DHEA. Therefore, the aim of this study was to evaluate the effect of different doses of DHEA on metabolic parameters of male and ovariectomized female Wistar rats. Sex differences were found in the metabolism of distinct substrates and in relation to the effect of DHEA. In respect to the glucose metabolism in the liver, the conversion of glucose to CO2 and the synthesis of lipids from glucose were 53% and 33% higher, respectively, in males. Also, DHEA decreased hepatic lipogenesis only in females. Regarding the hepatic glycogen synthesis pathway, females presented 73% higher synthesis than males, and the effect of DHEA was observed only in females, where it decreased this parameter. In the adipose tissue, glucose uptake was 208% higher in females and DHEA decreased this parameter. In the muscle, glucose uptake was 168% higher in females and no DHEA effect was observed. In summary, males and females present a different metabolic profile, with females being more susceptible to...Continue Reading

References

Jul 1, 1995·Experimental Animals·S MinematsuS Amagaya
Feb 15, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I L TorresC Dalmaz
Jun 20, 2001·Life Sciences·S MorimotoV Díaz-Sánchez
Aug 10, 2001·Neurochemical Research·I dos Santos FagundesM L Perr
Oct 16, 2001·International Review of Neurobiology·E E BaulieuM Schumacher
Oct 31, 2002·Metabolism: Clinical and Experimental·Mark J ManaryRobin L Broadhead
Oct 11, 2003·World Journal of Urology·Jacques Buvat
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Karen L Herbst, Shalender Bhasin
Nov 13, 2004·JAMA : the Journal of the American Medical Association·Dennis T Villareal, John O Holloszy
May 26, 2009·Progress in Lipid Research·Max Lafontan, Dominique Langin
Aug 25, 2009·Steroids·Maria Helena Vianna Metello JacobMaria Flavia Marques Ribeiro
Mar 27, 2010·Revista da Associação Médica Brasileira·Sueli Blanes DamyLuiz Francisco Poli de Figueiredo
Feb 26, 2011·Steroids·Matheus Parmegiani JahnLuiz Carlos Kucharski
Apr 14, 2011·The Journal of Physiology·João Paulo Gabriel CamporezCarla Roberta de Oliveira Carvalho
Jul 21, 2011·Journal of Nutrition and Metabolism·Betty N Wu, Anthony J O'Sullivan
Oct 29, 2011·The Journal of Sexual Medicine·Abdulmaged M TraishAndre T Guay
Jun 28, 2013·Adipocyte·Jenny C LinkKaren Reue
Jan 7, 2014·Mayo Clinic Proceedings·Michael D LeiseJayant A Talwalkar
Apr 16, 2014·BioMed Research International·Fernando Lizcano, Guillermo Guzmán
May 17, 2014·Nature·Janine A Clayton, Francis S Collins
Jul 16, 2014·Drugs·Krzysztof RutkowskiRyszard Rutkowski
Oct 11, 2014·Endocrine·Ana Lúcia CecconelloMaria Flávia Marques Ribeiro
Oct 17, 2014·Science Translational Medicine·Jayne S Danska
Jul 15, 2015·Journal of Bioscience and Bioengineering·Hiroaki TakedaTakeshi Bamba
Mar 1, 2016·Canadian Journal of Diabetes·Nicola VeroneseGiuseppe Sergi
Nov 23, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Claudia Vieira-MarquesMaria Flávia M Ribeiro

❮ Previous
Next ❯

Citations

Nov 13, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Caio Jordão TeixeiraCarla Roberta de Oliveira Carvalho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Steroid Biochemistry and Molecular Biology
Claudia Vieira-MarquesMaria Flávia Marques Ribeiro
International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
P MauriègeY Deshaies
© 2022 Meta ULC. All rights reserved