PMID: 3756525Sep 24, 1986Paper

Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin

Brain Research
G A KennettG Curzon

Abstract

A single 2-h restraint stress reduces locomotion and increases defaecation of male rats placed in an open field 24 h later. After daily 2-h restraints for 5 days these effects were no longer observed. This adaptation was associated with enhanced sensitivity to the serotonin agonist 5-methoxy-N,N-dimethyltryptamine. Female rats were less affected by a single restraint but failed to adapt to the repeated stress procedure and did not exhibit enhanced sensitivity to 5-methoxy-N,N-dimethyltryptamine. Furthermore, females but not males killed 24 h after the final restraint period had decreased brain regional 5-hydroxyindoleacetic acid concentrations particularly in the frontal cortex. No sex differences in hypothalamic and striatal dopamine metabolism were observed. The above differences between male and female rats were unaffected by adult gonadectomy. Similar differences could be involved in the higher incidence of depressive illness in women.

References

Mar 1, 1976·Neuropharmacology·C A Marsden, G Curzon
Jan 1, 1977·Archives of General Psychiatry·M M Weissman, G L Klerman
May 1, 1979·Pharmacology, Biochemistry, and Behavior·J F DeakinN K Macleod
May 1, 1978·Psychological Medicine·E S Paykel
May 1, 1976·AJS; American Journal of Sociology·B P Dohrenwend, B S Dohrenwend
Jul 1, 1985·The Journal of Nervous and Mental Disease·N PiranM Owens
Mar 1, 1985·The American Journal of Psychiatry·N F Damlouji, J M Ferguson
Sep 16, 1985·Brain Research·B B Turner, D A Weaver
Oct 1, 1980·Behavioral and Neural Biology·A D Sherman, F Petty
Oct 20, 1980·Life Sciences·S C Gerson, R J Baldessarini
Aug 1, 1982·Behavioral and Neural Biology·A D Sherman, F Petty
Jan 1, 1984·Psychopharmacology·P Willner
Oct 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·D J Cooke, D J Hole
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R J KatzB J Carroll

❮ Previous
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Citations

Jan 1, 1989·Journal of Neural Transmission·M Carlsson, A Carlsson
Jan 1, 1991·Psychopharmacology·M E Reith, C T Fischette
May 3, 2000·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·W P ParéS Tejani-Butt
Oct 3, 2000·Journal of Physiology and Biochemistry·S J AlonsoE Navarro
Apr 17, 2013·Pflügers Archiv : European journal of physiology·Nina C Donner, Christopher A Lowry
Sep 4, 2007·Neuroscience and Behavioral Physiology·D F AvgustinovichL A Koryakina
Aug 25, 1992·European Journal of Pharmacology·O ZamfirF Chaouloff
Jan 1, 1987·Physiology & Behavior·M MasE Battaner
May 1, 1993·Physiology & Behavior·M E Albonetti, F Farabollini
Dec 1, 1993·Physiology & Behavior·W P Paré, E Redei
Mar 1, 1995·Physiology & Behavior·M E Albonetti, F Farabollini
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·R P HeinsbroekN E Van de Poll
Nov 1, 1989·Pharmacology, Biochemistry, and Behavior·K OhiK Takahashi
Nov 1, 1990·Pharmacology, Biochemistry, and Behavior·R P HeinsbroekN E van de Poll
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·V A MolinaA M Basso
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·L UphouseM Caldarola-Pastuszka
Jan 1, 1991·Pharmacology, Biochemistry, and Behavior·V S MuruaV A Molina
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·T InoueI Yamashita
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·S MaswoodL Uphouse
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·T HataH Nishikawa
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·A SfikakisD Tsakayannis
Jan 1, 1990·Pharmacology & Therapeutics·P Willner
Jan 1, 1993·Brain Research. Brain Research Reviews·F Chaouloff
Feb 21, 1995·Journal of Affective Disorders·A M O'DwyerS A Checkley
Apr 1, 1991·Trends in Pharmacological Sciences·P Willner
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Carlsson, A Carlsson
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Curzon

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