PMID: 3749032Oct 1, 1986Paper

Female rats are protected against the fructose induced mortality of copper deficiency

Proceedings of the Society for Experimental Biology and Medicine
M FieldsJ C Smith

Abstract

Experiments were conducted in copper deficient male and female rats fed diets containing fructose or starch in order to determine whether the same type of interaction between copper status and dietary carbohydrate found in male rats also occurs in the female rat. Mortality occurred only in the male rats fed the fructose diet deficient in copper with 40% of the animals dying during the 8 week study. Only anemia, hypercholesterolemia, increased BUN, heart hypertrophy and reduced body weight were observed in these animals which could be related to their mortality. Despite the increased mortality, plasma ceruloplasmin, erythrocyte SOD and hepatic copper concentrations were reduced to a similar extent in all rats regardless of the sex of the animals or of the type of dietary carbohydrate fed. The results of the present study indicate that although direct measurements of copper status of female rats fed fructose diet deficient in copper are similar to their male counterpart, they are apparently protected from the lethal consequences of the deficiency.

Citations

Jan 5, 2000·BioFactors·J T Saari, D A Schuschke
Jul 15, 1994·Experientia·R S Bedwal, A Bahuguna
Dec 1, 1988·Biological Trace Element Research·H H Dollwet, J R Sorenson
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H M SchoenemannR W Rosebrough
Nov 1, 1988·Neurotoxicology and Teratology·M FieldsT Beal
Oct 25, 2000·The Journal of Nutritional Biochemistry·H Millo, M J Werman
Jun 14, 2003·Journal of the American College of Nutrition·Isabelle BureauYves Rayssiguier
Jul 1, 1990·Biological Trace Element Research·F H Nielsen
Jun 1, 1992·Metabolism: Clinical and Experimental·M FieldsM Lure
Mar 23, 2004·Acta histochemica·Małgorzata Kotula-BalakBarbara Bilińska
Nov 6, 2010·Nutrition & Metabolism·Salwa W Rizkalla
Aug 1, 1992·Journal of the American College of Nutrition·M FieldsM D Lure
Jun 1, 1993·Journal of the American College of Nutrition·M FieldsM D Lure
Mar 31, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ming SongCraig J McClain
Dec 1, 1990·Nutrition Reviews·B L O'Dell
Sep 27, 2002·Experimental Biology and Medicine·Jérôme BusserollesYves Rayssiguier

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