Female rats are resistant to developing the depressive phenotype induced by maternal separation stress

Metabolic Brain Disease
J J DimatelisV A Russell

Abstract

Many stress-related psychiatric disorders are more common in women than in men. We aimed to determine how female rats respond to maternal separation (MS; removal of the dam from the litter for 3 h/day from postnatal day (P) 2-14)). A subset of MS females were also exposed to chronic constant light for 3 weeks during adolescence (P42-63) to investigate whether the antidepressant effect of light treatment, previously observed in male rats, could be seen in female rats. Ultrasonic vocalizations (22 kHz) were recorded and the forced swim test was conducted immediately after light exposure (P65-67) and 33 days later (P98-99) to determine depressive-like behaviour. Key proteins in the MAPK signal transduction pathway (MKP-1, phospho-ERK, total ERK) and a synaptosomal marker (synaptophysin) were measured in the ventral hippocampus. We found that MS decreased the duration of 22 kHz vocalizations at P65 which was reversed by subsequent light. Light exposure increased time spent in the inner zone of the open field and the number of 22 kHz calls in response to novelty at P98. MS decreased the time females spent immobile and increased time actively swimming in the forced swim test at P67 but not at P99. MKP-1 and synaptophysin levels remai...Continue Reading

References

Feb 1, 1991·Physiology & Behavior·A L Johnston, S E File
Dec 1, 1993·Journal of Comparative Psychology·M Haney, K A Miczek
Nov 7, 2000·Reviews in the Neurosciences·J Lehmann, J Feldon
Mar 10, 2001·Nature·L Chang, M Karin
Oct 31, 2002·Psychological Bulletin·Brian KnutsonJaak Panksepp
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·D M BannermanJ Feldon
Jun 17, 2005·Psychoneuroendocrinology·Seymour Levine
Jun 29, 2005·Journal of Affective Disorders·Sheila M MarcusA John Rush
Sep 4, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Georgina M RenardMarta M Suárez
Mar 28, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lieve DesbonnetTimothy G Dinan
May 12, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ricardo LlorenteMaría-Paz Viveros
Jun 26, 2009·Psychoneuroendocrinology·M P ViverosL M Garcia-Segura
Oct 12, 2010·Nature Neuroscience·Freddy JeanneteauMoses V Chao
Oct 19, 2010·Nature Medicine·Vanja DuricRonald S Duman
Nov 6, 2010·Nature Medicine·Schahram Akbarian, Roger J Davis
Feb 15, 2011·Physiology & Behavior·Eduardo F Carvalho-NettoJames P Herman
Oct 6, 2011·Neuroscience Letters·Wataru IioAtsushi Toyoda

❮ Previous
Next ❯

Citations

Oct 1, 2019·Climacteric : the Journal of the International Menopause Society·M U UgurluB M Gulluoglu
Apr 6, 2018·Behavioural Neurology·Natalya P BondarVasiliy V Reshetnikov
Feb 11, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jade L ThorntonSarah J Baracz
May 1, 2021·Brain Sciences·Charles LenellMichelle R Ciucci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.