Female rats display enhanced rewarding effects of ethanol that are hormone dependent

Alcoholism, Clinical and Experimental Research
Oscar V TorresLaura E O'Dell

Abstract

Ethanol (EtOH) abuse is a major health and economic concern, particularly for females who appear to be more sensitive to the rewarding effects of EtOH. This study compared sex differences to the rewarding and aversive effects of EtOH using place-conditioning procedures in rats. Separate groups of adult (male, female, ovariectomized [OVX] female) and adolescent (male and female) rats received EtOH (0, 0.5, 1.0, 2.0, or 2.5 g/kg, intraperitoneal) and were confined to their initially nonpreferred side of our conditioning apparatus for 30 minutes. On alternate days, they received saline and were confined to the other side. Following 5 drug pairings, the rats were retested for preference behavior. Separate cohorts of the same groups of rats were injected with a similar dose range of EtOH, and blood EtOH levels (BELs) were compared 30 minutes later. EtOH produced rewarding or aversive effects in a dose-dependent manner. An intermediate dose of EtOH (1.0 g/kg) produced rewarding effects in adult female, but not in male or OVX female rats, suggesting that ovarian hormones facilitate the rewarding effects of EtOH. Similarly, this intermediate dose of EtOH produced rewarding effects in adolescent female, but not in male rats. The highest...Continue Reading

References

Sep 1, 1992·Alcohol·F E Lancaster, K S Spiegel
Nov 1, 1994·Journal of Studies on Alcohol·J L York, J W Welte
Jan 1, 1994·Alcohol·F van Haaren, K Anderson
Oct 1, 1993·Alcoholism, Clinical and Experimental Research·B A BlanchardS D Glick
Sep 1, 1996·Alcoholism, Clinical and Experimental Research·F E LancasterS B Wren
Apr 1, 1996·Archives of Neurology·D HommerM Eckardt
Nov 1, 1996·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·P BienkowskiW Kostowski
Jun 24, 1998·The Journal of Clinical Investigation·O F AlmeidaV K Patchev
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·A J RobertsG F Koob
May 27, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G Biała, J Kotlińska
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S L Blatt, R N Takahashi
Feb 19, 2000·Alcohol·M M Silveri, L P Spear
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·F SluyterA R Cools
Mar 19, 2002·Harvard Review of Psychiatry·Shelly F Greenfield
Jan 28, 2004·Alcoholism, Clinical and Experimental Research·Matthew M FordHerman H Samson
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Tara L FidlerChristopher L Cunningham
Sep 29, 2004·Nature Neuroscience·Cheryl L Sisk, Douglas L Foster
Jan 31, 2006·Pharmacology, Biochemistry, and Behavior·Richard L BellWilliam J McBride
Jul 15, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura DazziGiovanni Biggio
Mar 28, 2007·Alcoholism, Clinical and Experimental Research·Eric M TruxellNorman E Spear
Jun 26, 2007·Journal of Women & Aging·Elizabeth E EpsteinZayed Al-Otaiba
Jun 24, 2008·Pharmacology, Biochemistry, and Behavior·Oscar V TorresLaura E O'Dell
Oct 23, 2008·Pharmacology, Biochemistry, and Behavior·Brendan M Walker, Cindy L Ehlers
Apr 14, 2009·Alcohol·Yossef ItzhakKaren L Anderson
Sep 22, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Courtney Vetter-O'HagenLinda Spear
Nov 28, 2009·Brain and Cognition·Erika E Forbes, Ronald E Dahl
Feb 2, 2010·Alcohol·Antoniette M Maldonado-DevincciCheryl L Kirstein
Aug 10, 2011·Pharmacology, Biochemistry, and Behavior·Richard L BellWilliam J McBride
Aug 17, 2011·Neurotoxicology and Teratology·C Roger-SánchezJ Miñarro
Jun 9, 2012·Biology of Sex Differences·Jill B BeckerChristel Westenbroek

❮ Previous
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Citations

Sep 17, 2014·Current Psychiatry Reports·Megan M Moran-Santa MariaKathleen Brady
Jan 17, 2016·Pharmacological Reviews·Jill B Becker, George F Koob
Jan 2, 2016·Pharmacological Reviews·Styliani GoulopoulouR Clinton Webb
Jul 15, 2015·Journal of Neurotrauma·Zachary M WeilJohn D Corrigan
Apr 10, 2016·Behavioural Brain Research·Rodolfo J FloresLaura E O'Dell
Aug 2, 2014·Brain Structure & Function·T A RetsonE J Van Bockstaele
Jul 29, 2015·Pharmacology, Biochemistry, and Behavior·Heather E KingAnthony L Riley
Sep 15, 2016·Alcohol·Nicholas J JuryAndrew Holmes
Apr 29, 2015·Addiction Biology·Sema G QuadirKaren K Szumlinski
Dec 28, 2017·Addiction Biology·Almila ErolVictor M Karpyak
Nov 24, 2018·Addiction Biology·Sudarat NimitvilaiJohn J Woodward
Dec 19, 2019·Biology of Sex Differences·Angela M HenricksWilder T Doucette
Mar 1, 2020·Journal of Neurotrauma·John D CorriganJingzhen Yang
Aug 21, 2019·Stress : the International Journal on the Biology of Stress·Kamila Souto LeichtweisVanessa Cristiane Santana Amaral
May 31, 2020·Alcoholism, Clinical and Experimental Research·Elizabeth A SneddonAnna K Radke
Jun 12, 2018·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Keith L WilliamsJustin T Bielak
Mar 10, 2017·Frontiers in Behavioral Neuroscience·Armando LárragaFrances M Leslie
Dec 22, 2017·Alcoholism, Clinical and Experimental Research·Salvador Huitron-ResendizAmanda J Roberts
Aug 2, 2019·Brain Sciences·Chelsea R KastenTiffany A Wills
Mar 20, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Hannah D FulenwiderJesse R Schank
Jan 8, 2021·Psychopharmacology·Ranjithkumar ChellianAdriaan W Bruijnzeel
Nov 2, 2019·Neuroscience and Biobehavioral Reviews·Roberto U CofresíThomas M Piasecki
Apr 20, 2020·Journal of the Neurological Sciences·Sabrina SwensonPanayotis K Thanos
Jul 19, 2020·Neuroscience and Biobehavioral Reviews·Craig D C BaileyCheryl M McCormick
Aug 21, 2021·Pharmacology, Biochemistry, and Behavior·Eleanor Blair Towers, Wendy J Lynch
Dec 12, 2017·ACS Chemical Neuroscience·Elisa R Hilderbrand, Amy W Lasek
Sep 21, 2021·Bulletin of Experimental Biology and Medicine·L G KolikA D Durnev

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