Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males

The American Journal of Physiology
Y IimuroR G Thurman

Abstract

It is known that women develop hepatic injury more rapidly and with exposure to less ethanol than men; however, mechanisms remain unclear. The purpose of this study was to determine if an enteral alcohol delivery model could be used to study susceptibility of females to alcohol-induced liver injury. Male and female Wistar rats (age- or weight-matched) were given ethanol (11-12 g.kg-1.day-1) continuously for up to 4 wk via intragastric feeding, and control rats received a high-fat diet without ethanol. There were no significant differences in body weight among the groups studied. Furthermore, mean ethanol concentrations, their cyclic pattern in urine, and rates of ethanol elimination were also not different between the genders under these conditions. Ethanol treatment elevated serum aspartate aminotransferase levels in male rats to 126 +/- 10 IU/l after 4 wk. In females, however, values increased more rapidly and reached significantly higher values at 4 wk (168 +/- 18 IU/l). Steatosis, inflammation, and necrosis assessed histologically also developed more rapidly and were more severe in females than males. Steatosis due to ethanol exposure, which was localized in centrilobular areas in males, was panlobular in the female. Moreov...Continue Reading

Citations

Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A A NanjiA J Dannenberg
Aug 17, 2002·Journal of Applied Physiology·Stasa D TadicPatricia K Eagon
Oct 4, 2014·World Journal of Gastroenterology : WJG·Jessica A WilliamsWen-Xing Ding
Jan 19, 2018·Biomolecules·Shubha Ghosh DastidarIrina A Kirpich
Jun 10, 2003·Journal of Applied Physiology·C A RiveraC W Smith
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·H KonoR G Thurman
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·H KonoR G Thurman
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·K J Atkinson, R K Rao
Jan 1, 2007·Toxicology Mechanisms and Methods·Shashi K Ramaiah, Hartmut Jaeschke
Apr 14, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·H KonoR G Thurman
Mar 11, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·H KonoR G Thurman
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·H KonoR G Thurman

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